Seroatlas · Human Serome Atlas

MAGED1

Melanoma-associated antigen D1

Also known as: DLXIN-1, MAGD1_HUMAN, NRAGE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5V3
Gene: MAGED1
Ensembl: ENSG00000179222
Chromosome: X
Canonical length: 778 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homomultimer

OverviewNCBI Gene

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

778 residues, UniProt reviewed canonical sequence.

>Q9Y5V3|MAGED1
     1  MAQKMDCGAG LLGFQAEASV EDSALLMQTL MEAIQISEAP PTNQATAAAS PQSSQPPTAN
    61  EMADIQVSAA AARPKSAFKV QNATTKGPNG VYDFSQAHNA KDVPNTQPKA AFKSQNATPK
   121  GPNAAYDFSQ AATTGELAAN KSEMAFKAQN ATTKVGPNAT YNFSQSLNAN DLANSRPKTP
   181  FKAWNDTTKA PTADTQTQNV NQAKMATSQA DIETDPGISE PDGATAQTSA DGSQAQNLES
   241  RTIIRGKRTR KINNLNVEEN SSGDQRRAPL AAGTWRSAPV PVTTQNPPGA PPNVLWQTPL
   301  AWQNPSGWQN QTARQTPPAR QSPPARQTPP AWQNPVAWQN PVIWPNPVIW QNPVIWPNPI
   361  VWPGPVVWPN PLAWQNPPGW QTPPGWQTPP GWQGPPDWQG PPDWPLPPDW PLPPDWPLPT
   421  DWPLPPDWIP ADWPIPPDWQ NLRPSPNLRP SPNSRASQNP GAAQPRDVAL LQERANKLVK
   481  YLMLKDYTKV PIKRSEMLRD IIREYTDVYP EIIERACFVL EKKFGIQLKE IDKEEHLYIL
   541  ISTPESLAGI LGTTKDTPKL GLLLVILGVI FMNGNRASEA VLWEALRKMG LRPGVRHPLL
   601  GDLRKLLTYE FVKQKYLDYR RVPNSNPPEY EFLWGLRSYH ETSKMKVLRF IAEVQKRDPR
   661  DWTAQFMEAA DEALDALDAA AAEAEARAEA RTRMGIGDEA VSGPWSWDDI EFELLTWDEE
   721  GDFGDPWSRI PFTFWARYHQ NARSRFPQTF AGPIIGPGGT ASANFAANFG AIGFFWVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 159 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 159 nTPM
pituitary gland: 149 nTPM
adrenal gland: 118 nTPM
hypothalamus: 117 nTPM
placenta: 109 nTPM
cerebral cortex: 109 nTPM

Single-cell type

sertoli cells: 480 nCPM
cytotrophoblasts: 425 nCPM
choroid plexus epithelial cells: 345 nCPM
somatotrophs: 302 nCPM
thyrotrophs: 269 nCPM
migrating cytotrophoblasts: 264 nCPM

Immune cell

plasmacytoid DC: 56 nTPM
gdT-cell: 21 nTPM
T-reg: 21 nTPM
naive CD8 T-cell: 21 nTPM
naive B-cell: 20 nTPM
MAIT T-cell: 19 nTPM

Brain region

hypothalamus: 245 nTPM
choroid plexus: 226 nTPM
pons: 179 nTPM
basal ganglia: 165 nTPM
hippocampal formation: 163 nTPM
cerebral cortex: 160 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAGED1.

Disease | ImmuneIEDB

Conditions an epitope on MAGED1 was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.33
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAGED1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGED1 as an antibody target. Whether an autoantibody or antibody against MAGED1 could matter depends on whether native MAGED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGED1 is annotated at the cell surface, where native MAGED1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAGED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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