Seroatlas · Human Serome Atlas

LZTS2

Leucine zipper putative tumor suppressor 2

Also known as: KIAA1813, LAPSER1, LZTS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRK4
Gene
LZTS2
Ensembl
ENSG00000107816
Chromosome
10
Canonical length
669 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

669 residues, UniProt reviewed canonical sequence.

>Q9BRK4|LZTS2
     1  MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP PGPTFFRQQD
    61  GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP PSPSSDVEDA REQRAHNAHL
   121  RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT
   181  QLFGGPASSS SSSSSSSAAD KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT
   241  SSPGGHLPSH GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA
   301  SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN EATMCQAYEE
   361  RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE KRQLQDDFAQ LLQEREQLER
   421  RCATLEREQR ELGPRLEETK WEVCQKSGEI SLLKQQLKES QAELVQKGSE LVALRVALRE
   481  ARATLRVSEG RARGLQEAAR ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP
   541  PVPPATADPF LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER
   601  LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL GLAEQAPCIC
   661  LEEITATEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LZTS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
103 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 103 nTPM
  • colon: 92 nTPM
  • endometrium: 84 nTPM
  • urinary bladder: 84 nTPM
  • spinal cord: 83 nTPM
  • ovary: 74 nTPM

Single-cell type

  • tuft cells: 69 nCPM
  • oligodendrocytes: 63 nCPM
  • syncytiotrophoblasts: 58 nCPM
  • smooth muscle cells: 48 nCPM
  • vascular smooth muscle cells: 43 nCPM
  • hofbauer cells: 40 nCPM

Immune cell

  • MAIT T-cell: 3.7 nTPM
  • naive CD4 T-cell: 3.5 nTPM
  • memory CD4 T-cell: 3.4 nTPM
  • memory CD8 T-cell: 3 nTPM
  • naive CD8 T-cell: 3 nTPM
  • T-reg: 3 nTPM

Brain region

  • white matter: 133 nTPM
  • thalamus: 110 nTPM
  • midbrain: 108 nTPM
  • basal ganglia: 107 nTPM
  • medulla oblongata: 106 nTPM
  • cerebral cortex: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.05
gnomAD missense Z
0.73
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LZTS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LZTS2 as an antibody target. Whether an autoantibody or antibody against LZTS2 could matter depends on whether native LZTS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LZTS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LZTS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LZTS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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