Seroatlas · Human Serome Atlas

RIMBP3

RIMS-binding protein 3A

Also known as: KIAA1666, RIM3A_HUMAN, RIMBP3.1, RIMBP3A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UFD9
Gene: RIMBP3
Ensembl: ENSG00000275793
Chromosome: 22
Canonical length: 1639 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable benzodiazepine receptor binding activity. Predicted to be involved in fertilization and spermatid development. Predicted to be located in manchette. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1639 residues, UniProt reviewed canonical sequence.

>Q9UFD9|RIMBP3
     1  MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE RRRFAARERQ
    61  LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE AEIRQLLRWK EAEQRQLQQL
   121  LHRERDGVVR QARELQRQLA EELVNRGHCS RPGASEVSAA QCRCRLQEVL AQLRWQTDGE
   181  QAARIRYLQA ALEVERQLFL KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP
   241  KPACQLGSLD SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR
   301  SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG EGSESQPCEV
   361  LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQAENKQ LRRAGCPYQA DEKVKRLKVK
   421  RAELTGLARR LADRARKLQE TNLRAVSAPI PGESCAGLEL CQVFARQRAR DLSEQASAPL
   481  AKDKQIEELR QECHLLQARV ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ
   541  RQLMLQQGNG GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGAQ AAPARRRGEE
   601  AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER DASGLIAEQL
   661  LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG HPPEQPWETS QMPESQVKGS
   721  RRPKFHARPE DYAVSQPNRD IQEKREASLE ESPVALGESA SVPQVSETVP ASQPLSKKTS
   781  SQSNSSSEGS MWATVPSSPT LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ
   841  YNYNPFEGPN DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LEDGRRGLVP SNFVEQIPDS
   901  YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGVV DRGLCQMVRV GSKTEVATEI
   961  LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH LQNVTATSAN ITWVYSSHRH
  1021  PHVVYLDDRE HALTPAGVSC YTFQGLCPGT HYRARVEVRL PRDLLQVYWG TMSSTVTFDT
  1081  LLAGPPYPPL DVLVERHASP GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD
  1141  ATAGSTLLEF SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT
  1201  CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP PRRQSPVSNL
  1261  GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP PSVSDQPGEK ENCSQHMGTS
  1321  KSPAPGFIHL RTECGPRKEP CQEKAALERV LRQKQDAQGF TPPQLGASQQ YASDFHNVLK
  1381  EEQEALCLDL WGTERREERR EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR
  1441  GGPQQLGTGA NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL
  1501  SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGNLPSV AHLEDFQGLT IPQGSSLVLQ
  1561  GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG DVVMVYGPMD DQGFYYGELG
  1621  GHRGLVPAHL LDHMSLHGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIMBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
thymus: 0.9 nTPM
lymph node: 0.7 nTPM
spleen: 0.6 nTPM
tonsil: 0.5 nTPM
appendix: 0.3 nTPM

Single-cell type

late spermatids: 0.6 nCPM
megakaryocyte-erythroid progenitors: 0.4 nCPM
early spermatids: 0.3 nCPM
cdc: 0.2 nCPM
late primary spermatocytes: 0.2 nCPM
megakaryocyte progenitors: 0.2 nCPM

Immune cell

MAIT T-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

hypothalamus: 8.7 nTPM
midbrain: 7 nTPM
medulla oblongata: 6.6 nTPM
pons: 6.5 nTPM
basal ganglia: 6.4 nTPM
spinal cord: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

benzodiazepine receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIMBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIMBP3 as an antibody target. Whether an autoantibody or antibody against RIMBP3 could matter depends on whether native RIMBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIMBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIMBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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