Seroatlas · Human Serome Atlas

IHO1

Interactor of HORMAD1 protein 1

Also known as: CCDC36, CT74, FLJ25320, IHO1_HUMAN, LELA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYA8
Gene
IHO1
Ensembl
ENSG00000173421
Chromosome
3
Canonical length
594 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in several processes, including meiosis I cell cycle process; regulation of homologous chromosome segregation; and spermatogenesis. Predicted to be located in chromosome. Predicted to be active in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q8IYA8|IHO1
     1  MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE NSETLSAPLD
    61  FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG GLFPPPLSVG KSKGLLEQFE
   121  EKKKRAKDKC DSETLYNFVS NVRESILRLQ TSVEKSEDHL SSRSQSILDS LETVAKTLQE
   181  TIQAQNDLVF EAVQDKGNME QAILEMKKRF EARQGEFIEM KSNLKHLEVL VAQQSQEFQQ
   241  LCEQLGQLNV PSVLAELKRL ISVPPVKDSA SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ
   301  ALPAAWNPGM GSLQPGEFDV WGEGAKNDDL QEEAALPAFG SHERNRHVKD KVVQTNCKNW
   361  AVTKTGAKNH GSSVPGHKIP SDRDLVSQGA SQLTSLEINF STSIKNACQK YQAQSMFLCD
   421  PREHLVIKQK DGTVEMRGKD KKQQPRKAHR AHRGRLIASK QKQIPIQTCK FNSKYQSPQP
   481  AISVPQSPFL GQQEPRAQPL HLQCPRSPRK PVCPILGGTV MPNKTVRAVQ GRLLQLSRCS
   541  SQDNWLLSSS SQGDHQMSWF SDLNLGCSET PLCKEAGKNL LYDLGFDSSD DDGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IHO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • testis: 24 nTPM
  • ovary: 3.6 nTPM
  • adipose tissue: 3 nTPM
  • breast: 1.7 nTPM
  • adrenal gland: 1.3 nTPM
  • choroid plexus: 1.2 nTPM

Single-cell type

  • early primary spermatocytes: 425 nCPM
  • adipocytes: 136 nCPM
  • late primary spermatocytes: 125 nCPM
  • myonuclei: 82 nCPM
  • choroid plexus epithelial cells: 74 nCPM
  • early spermatids: 69 nCPM

Immune cell

  • neutrophil: 0.6 nTPM
  • basophil: 0.3 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • cerebellum: 3.9 nTPM
  • cerebral cortex: 3.5 nTPM
  • thalamus: 3.2 nTPM
  • hippocampal formation: 2.9 nTPM
  • midbrain: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.02
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Interactor of HORMAD1 protein 1
  • Interactor of HORMAD1 protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IHO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IHO1 as an antibody target. Whether an autoantibody or antibody against IHO1 could matter depends on whether native IHO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IHO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IHO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IHO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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