Seroatlas · Human Serome Atlas

PRDM14

PR domain zinc finger protein 14

Also known as: PRD14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZV8
Gene: PRDM14
Ensembl: ENSG00000147596
Chromosome: 8
Canonical length: 571 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

571 residues, UniProt reviewed canonical sequence.

>Q9GZV8|PRDM14
     1  MALPRPSEAV PQDKVCYPPE SSPQNLAAYY TPFPSYGHYR NSLATVEEDF QPFRQLEAAA
    61  SAAPAMPPFP FRMAPPLLSP GLGLQREPLY DLPWYSKLPP WYPIPHVPRE VPPFLSSSHE
   121  YAGASSEDLG HQIIGGDNES GPCCGPDTLI PPPPADASLL PEGLRTSQLL PCSPSKQSED
   181  GPKPSNQEGK SPARFQFTEE DLHFVLYGVT PSLEHPASLH HAISGLLVPP DSSGSDSLPQ
   241  TLDKDSLQLP EGLCLMQTVF GEVPHFGVFC SSFIAKGVRF GPFQGKVVNA SEVKTYGDNS
   301  VMWEIFEDGH LSHFIDGKGG TGNWMSYVNC ARFPKEQNLV AVQCQGHIFY ESCKEIHQNQ
   361  ELLVWYGDCY EKFLDIPVSL QVTEPGKQPS GPSEESAEGY RCERCGKVFT YKYYRDKHLK
   421  YTPCVDKGDR KFPCSLCKRS FEKRDRLRIH ILHVHEKHRP HKCSTCGKCF SQSSSLNKHM
   481  RVHSGDRPYQ CVYCTKRFTA SSILRTHIRQ HSGEKPFKCK YCGKSFASHA AHDSHVRRSH
   541  KEDDGCSCSI CGKIFSDQET FYSHMKFHED Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDM14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

testis: 0.7 nTPM
bone marrow: 0.2 nTPM
choroid plexus: 0.2 nTPM
retina: 0.2 nTPM
duodenum: 0.1 nTPM
epididymis: 0.1 nTPM

Single-cell type

hepatic stellate cells: 6.5 nCPM
thymocytes: 3.4 nCPM
undifferentiated spermatogonia: 2.6 nCPM
cone photoreceptor cells: 2.1 nCPM
breast secretory cells: 0.7 nCPM
endometrial stromal cells: 0.7 nCPM

Immune cell

neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 2.1 nTPM
white matter: 2 nTPM
cerebral cortex: 1.8 nTPM
choroid plexus: 1.8 nTPM
medulla oblongata: 1.6 nTPM
pons: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.02
gnomAD missense Z: 1.88
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin DNA binding
histone methyltransferase binding
methyltransferase activity
RNA binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
zinc ion binding
methyltransferase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRDM14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRDM14 as an antibody target. Whether an autoantibody or antibody against PRDM14 could matter depends on whether native PRDM14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRDM14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRDM14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...