Seroatlas · Human Serome Atlas

STX19

Syntaxin-19

Also known as: MGC21382, STX19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4C7
Gene: STX19
Ensembl: ENSG00000178750
Chromosome: 3
Canonical length: 294 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; synaptic vesicle fusion to presynaptic active zone membrane; and vesicle docking. Predicted to be located in cytoplasm and membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q8N4C7|STX19
     1  MKDRLQELKQ RTKEIELSRD SHVSTTETEE QGVFLQQAVI YEREPVAERH LHEIQKLQES
    61  INNLADNVQK FGQQQKSLVA SMRRFSLLKR ESTITKEIKI QAEYINRSLN DLVKEVKKSE
   121  VENGPSSVVT RILKSQHAAM FRHFQQIMFI YNDTIAAKQE KCKTFILRQL EVAGKEMSEE
   181  DVNDMLHQGK WEVFNESLLT EINITKAQLS EIEQRHKELV NLENQIKDLR DLFIQISLLV
   241  EEQGESINNI EMTVNSTKEY VNNTKEKFGL AVKYKKRNPC RVLCCWCCPC CSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

epididymis: 15 nTPM
rectum: 13 nTPM
colon: 12 nTPM
skin: 8.6 nTPM
salivary gland: 8.3 nTPM
small intestine: 7.7 nTPM

Single-cell type

esophageal apical cells: 90 nCPM
epicardial cells: 86 nCPM
rod photoreceptor cells: 82 nCPM
colonocytes: 73 nCPM
goblet cells: 62 nCPM
breast lactating cells: 58 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 10 nTPM
cerebral cortex: 3.6 nTPM
midbrain: 3.6 nTPM
basal ganglia: 3.3 nTPM
cerebellum: 3.3 nTPM
medulla oblongata: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.46
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX19 as an antibody target. Whether an autoantibody or antibody against STX19 could matter depends on whether native STX19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX19 is annotated at the cell surface, where native STX19 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STX19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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