Seroatlas · Human Serome Atlas

CTTNBP2

Cortactin-binding protein 2

Also known as: C7orf8, CORTBP2, CTTB2_HUMAN, KIAA1758, Orf4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WZ74
Gene: CTTNBP2
Ensembl: ENSG00000077063
Chromosome: 7
Canonical length: 1663 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Midbody ring,Cytosol

OverviewNCBI Gene

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1663 residues, UniProt reviewed canonical sequence.

>Q8WZ74|CTTNBP2
     1  MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE
    61  ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK KPVCTNPLSI LEAVMAHCKK
   121  MQERMSAQLA AAESRQKKLE MEKLQLQALE QEHKKLAARL EEERGKNKQV VLMLVKECKQ
   181  LSGKVIEEAQ KLEDVMAKLE EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ
   241  LRAKLNREEA HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT
   301  VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT MARPGIDRQA
   361  SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP LPSNAAPPTA QTPGIAPQNS
   421  QAPPMHSLHS PCANTSLHPG LNPRIQAARF RFQGNANDPD QNGNTTQSPP SRDVSPTSRD
   481  NLVAKQLARN TVTQALSRFT SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG
   541  NPPPIPPKKP GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE
   601  ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA CSDSSLVIPT
   661  TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ
   721  GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV RLLLSAEAQV NAADKNGFTP
   781  LCAAAAQGHF ECVELLISYD ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT
   841  TDGWTPVHAA VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV
   901  VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV HDVATDDCKH
   961  LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI RKQTSWDDFS KAVSQALTNH
  1021  FQAISSDGWW SLEDVTCNNT TDSNIGLSAR SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK
  1081  AEHITVLLSG PQEGCLSSVT YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL
  1141  ALCLKHRQMA AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL
  1201  EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA KACLQGSDLL
  1261  VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP CDPVCKIVDW ALSVWRQLNS
  1321  CLARLGTPEA LLGPKYFLSC PVVPGHAQVT VKWMSKLWNG VIAPRVQEAI LSRASVKRQP
  1381  GFGQTTAKRH PSQGQQAVVK AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS
  1441  SYNTCNKKKG ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL
  1501  SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA DSRDDLRMFD
  1561  SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS KTELGVSRVK SFLPVPRSKV
  1621  TQCSQNTKRS SSSSNTRQIE INNNSKEVNW NLHKNEHLEK PNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTTNBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 13 nTPM
esophagus: 12 nTPM
basal ganglia: 11 nTPM
hippocampal formation: 11 nTPM
midbrain: 11 nTPM
endometrium: 9.2 nTPM

Single-cell type

oligodendrocyte progenitor cells: 602 nCPM
oligodendrocytes: 459 nCPM
mast cells: 355 nCPM
podocytes: 316 nCPM
retinal amacrine cells: 307 nCPM
microglia: 300 nCPM

Immune cell

non-classical monocyte: 7.9 nTPM
intermediate monocyte: 0.8 nTPM
classical monocyte: 0.3 nTPM
myeloid DC: 0.3 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 59 nTPM
basal ganglia: 42 nTPM
pons: 41 nTPM
medulla oblongata: 41 nTPM
cerebral cortex: 40 nTPM
thalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH3 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTTNBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTTNBP2 as an antibody target. Whether an autoantibody or antibody against CTTNBP2 could matter depends on whether native CTTNBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTTNBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CTTNBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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