Seroatlas · Human Serome Atlas

PPME1

Protein phosphatase methylesterase 1

Also known as: ABDH19, PME-1, PPME1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y570
Gene
PPME1
Ensembl
ENSG00000214517
Chromosome
11
Canonical length
386 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>Q9Y570|PPME1
     1  MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF ESMEDVEVEN
    61  ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII SRVQCRIVAL DLRSHGETKV
   121  KNPEDLSAET MAKDVGNVVE AMYGDLPPPI MLIGHSMGGA IAVHTASSNL VPSLLGLCMI
   181  DVVEGTAMDA LNSMQNFLRG RPKTFKSLEN AIEWSVKSGQ IRNLESARVS MVGQVKQCEG
   241  ITSPEGSKSI VEGIIEEEEE DEEGSESISK RKKEDDMETK KDHPYTWRIE LAKTEKYWDG
   301  WFRGLSNLFL SCPIPKLLLL AGVDRLDKDL TIGQMQGKFQ MQVLPQCGHA VHEDAPDKVA
   361  EAVATFLIRH RFAEPIGGFQ CVFPGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPME1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 59 nTPM
  • cerebral cortex: 40 nTPM
  • cerebellum: 35 nTPM
  • skeletal muscle: 34 nTPM
  • testis: 30 nTPM
  • epididymis: 28 nTPM

Single-cell type

  • endometrial ciliated cells: 174 nCPM
  • erythrocyte progenitors: 150 nCPM
  • pancreatic islet cells: 145 nCPM
  • gonadotrophs: 140 nCPM
  • pituicytes/fscs: 140 nCPM
  • myonuclei: 130 nCPM

Immune cell

  • NK-cell: 14 nTPM
  • memory CD4 T-cell: 13 nTPM
  • naive CD4 T-cell: 13 nTPM
  • MAIT T-cell: 13 nTPM
  • memory CD8 T-cell: 13 nTPM
  • plasmacytoid DC: 12 nTPM

Brain region

  • cerebral cortex: 59 nTPM
  • hypothalamus: 56 nTPM
  • pons: 53 nTPM
  • hippocampal formation: 52 nTPM
  • basal ganglia: 52 nTPM
  • midbrain: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
1.75
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPME1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPME1 as an antibody target. Whether an autoantibody or antibody against PPME1 could matter depends on whether native PPME1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPME1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPME1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPME1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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