Seroatlas · Human Serome Atlas

STK24

Serine/threonine-protein kinase 24

Also known as: MST-3, MST3, MST3B, STE20, STK24_HUMAN, STK3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6E0
Gene: STK24
Ensembl: ENSG00000102572
Chromosome: 13
Canonical length: 443 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q9Y6E0|STK24
     1  MDSRAQLWGL ALNKRRATLP HPGGSTNLKA DPEELFTKLE KIGKGSFGEV FKGIDNRTQK
    61  VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS YLKDTKLWII MEYLGGGSAL
   121  DLLEPGPLDE TQIATILREI LKGLDYLHSE KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ
   181  LTDTQIKRNT FVGTPFWMAP EVIKQSAYDS KADIWSLGIT AIELARGEPP HSELHPMKVL
   241  FLIPKNNPPT LEGNYSKPLK EFVEACLNKE PSFRPTAKEL LKHKFILRNA KKTSYLTELI
   301  DRYKRWKAEQ SHDDSSSEDS DAETDGQASG GSDSGDWIFT IREKDPKNLE NGALQPSDLD
   361  RNKMKDIPKR PFSQCLSTII SPLFAELKEK SQACGGNLGS IEELRGAIYL AEEACPGISD
   421  TMVAQLVQRL QRYSLSGGGT SSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 162 nTPM

Expression across tissuesHPA

Tissue

esophagus: 162 nTPM
skin: 147 nTPM
vagina: 110 nTPM
cervix: 98 nTPM
small intestine: 89 nTPM
blood vessel: 86 nTPM

Single-cell type

esophageal apical cells: 1,281 nCPM
urothelial cells: 644 nCPM
foveolar cells: 530 nCPM
platelets: 448 nCPM
endometrial glandular cells: 383 nCPM
respiratory secretory cells: 365 nCPM

Immune cell

T-reg: 14 nTPM
non-classical monocyte: 14 nTPM
classical monocyte: 13 nTPM
intermediate monocyte: 11 nTPM
myeloid DC: 11 nTPM
neutrophil: 11 nTPM

Brain region

choroid plexus: 85 nTPM
thalamus: 67 nTPM
midbrain: 55 nTPM
cerebellum: 52 nTPM
hippocampal formation: 52 nTPM
cerebral cortex: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.01
gnomAD missense Z: 1.99
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STK24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK24 as an antibody target. Whether an autoantibody or antibody against STK24 could matter depends on whether native STK24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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