Seroatlas · Human Serome Atlas

MOB4

MOB-like protein phocein

Also known as: 2C4D, CGI-95, DKFZP564M112, MOB3, MOBKL3, PHOCN, PHOCN_HUMAN, PREI3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3A3
Gene: MOB4
Ensembl: ENSG00000115540
Chromosome: 2
Canonical length: 225 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q9Y3A3|MOB4
     1  MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD CSNIDKILEP
    61  PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM TATEQWIFLC AAHKTPKECP
   121  AIDYTRHTLD GAACLLNSNK YFPSRVSIKE SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE
   181  YENETFLCHR FTKFVMKYNL MSKDNLIVPI LEEEVQNSVS GESEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 91 nTPM
bone marrow: 61 nTPM
esophagus: 40 nTPM
heart muscle: 39 nTPM
tongue: 35 nTPM
skeletal muscle: 34 nTPM

Single-cell type

syncytiotrophoblasts: 453 nCPM
esophageal apical cells: 237 nCPM
cytotrophoblasts: 170 nCPM
extravillous trophoblasts: 127 nCPM
migrating cytotrophoblasts: 122 nCPM
esophageal suprabasal cells: 116 nCPM

Immune cell

basophil: 25 nTPM
neutrophil: 23 nTPM
eosinophil: 18 nTPM
T-reg: 17 nTPM
NK-cell: 15 nTPM
naive CD8 T-cell: 14 nTPM

Brain region

cerebral cortex: 42 nTPM
cerebellum: 32 nTPM
white matter: 28 nTPM
hypothalamus: 27 nTPM
spinal cord: 27 nTPM
thalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.93
gnomAD missense Z: 2.38
DepMap mean gene effect: -0.62
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of hippo signaling

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOB4 as an antibody target. Whether an autoantibody or antibody against MOB4 could matter depends on whether native MOB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...