Seroatlas · Human Serome Atlas

STRIP2

Striatin-interacting protein 2

Also known as: FAM40B, FAR11B, KIAA1170, STRP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULQ0
Gene: STRIP2
Ensembl: ENSG00000128578
Chromosome: 7
Canonical length: 834 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in cell migration; cytoskeleton organization; and regulation of cell shape. Located in cytosol. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

834 residues, UniProt reviewed canonical sequence.

>Q9ULQ0|STRIP2
     1  MEDPAAPGTG GPPANGNGNG GGKGKQAAPK GREAFRSQRR ESEGSVDCPT LEFEYGDADG
    61  HAAELSELYS YTENLEFTNN RRCFEEDFKT QVQGKEWLEL EEDAQKAYIM GLLDRLEVVS
   121  RERRLKVARA VLYLAQGTFG ECDSEVDVLH WSRYNCFLLY QMGTFSTFLE LLHMEIDNSQ
   181  ACSSALRKPA VSIADSTELR VLLSVMYLMV ENIRLERETD PCGWRTARET FRTELSFSMH
   241  NEEPFALLLF SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQTL KVQKRAELGL
   301  PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG RRGSRRQLLT KQDSLDIYNE
   361  RDLFKTEEPA TEEEEESAGD GERTLDGELD LLEQDPLVPP PPSQAPLSAE RVAFPKGLPW
   421  APKVRQKDIE HFLEMSRNKF IGFTLGQDTD TLVGLPRPIH ESVKTLKQHK YISIADVQIK
   481  NEEELEKCPM SLGEEVVPET PCEILYQGML YSLPQYMIAL LKILLAAAPT SKAKTDSINI
   541  LADVLPEEMP ITVLQSMKLG IDVNRHKEII VKSISTLLLL LLKHFKLNHI YQFEYVSQHL
   601  VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL PELTTESLEA GDNSQFCWRN
   661  LFSCINLLRL LNKLTKWKHS RTMMLVVFKS APILKRALKV KQAMLQLYVL KLLKLQTKYL
   721  GRQWRKSNMK TMSAIYQKVR HRMNDDWAYG NDIDARPWDF QAEECTLRAN IEAFNSRRYD
   781  RPQDSEFSPV DNCLQSVLGQ RLDLPEDFHY SYELWLEREV FSQPICWEEL LQNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 44 nTPM
basal ganglia: 34 nTPM
skeletal muscle: 27 nTPM
retina: 21 nTPM
tongue: 18 nTPM
testis: 14 nTPM

Single-cell type

retinal pigment epithelial cells: 989 nCPM
choroid plexus epithelial cells: 597 nCPM
early primary spermatocytes: 214 nCPM
brain inhibitory neurons: 208 nCPM
müller glia: 165 nCPM
myonuclei: 113 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

choroid plexus: 178 nTPM
basal ganglia: 92 nTPM
thalamus: 25 nTPM
midbrain: 23 nTPM
cerebral cortex: 17 nTPM
hippocampal formation: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STRIP2.

Disease | ImmuneIEDB

Conditions an epitope on STRIP2 was assayed in.

colorectal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRIP2 as an antibody target. Whether an autoantibody or antibody against STRIP2 could matter depends on whether native STRIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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