Seroatlas · Human Serome Atlas

PRR14

Proline-rich protein 14

Also known as: MGC3121, PRR14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BWN1
Gene
PRR14
Ensembl
ENSG00000156858
Chromosome
16
Canonical length
585 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q9BWN1|PRR14
     1  MDLPGDSSPP GQPRLCRQPL TRALWGARSP KRPRLQLPGA PSPLEKASRR VLAVVLEDVM
    61  AVHMVPVVPS KQTSIPQHHS YHQDPVHRQP PASPPRQAGW SSQARPPDPL CLCREPLSRI
   121  HRTSSTLRRR SRTTPGPEEG PSQKVDRAPQ PTLVVMLEDI ASPRPPAEGF IDETPNFIIP
   181  AQRAEPMRIV RQPTPPPGDL EPPFQPSALP ADPLESPPTA PDPALELPST PPPSSLLRPR
   241  LSPWGLAPLF RSVRSKLESF ADIFLTPNKT PQPPPPSPPM KLELKIAISE AEQSGAAEGT
   301  ASVSPRPPIR QWRTQDHNTP ALLPKPSLGR SYSCPDLGPP GPGTCTWPPA PPQPSRPRPR
   361  RHTVGGGEMA RAPPPPRPCL RKEVFPLGGV GASPSLTTSC SSTASTSFSE PAEPRLGSTK
   421  GKEPRASKDQ VLSEPETKTM GKVSRFRIRR TPARPQLNLT PMGLPRPIRL NKKEFSLEEI
   481  YTNKNYQSPT TRRTFETIFE EPRERNGTLI FTSSRKLRRA VEFRDSSLPR SRRPSRGVRA
   541  AGGRTVPPNV APSPDVGPLL QQRLEELDAL LLEEETVDRE QPHWT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 38 nTPM
  • spleen: 34 nTPM
  • colon: 31 nTPM
  • endometrium: 30 nTPM
  • blood vessel: 29 nTPM
  • cervix: 28 nTPM

Single-cell type

  • neutrophils: 46 nCPM
  • esophageal apical cells: 32 nCPM
  • megakaryocytes: 31 nCPM
  • esophageal basal cells: 30 nCPM
  • epididymal efferent duct absorptive cells: 29 nCPM
  • breast myoepithelial cells: 28 nCPM

Immune cell

  • eosinophil: 24 nTPM
  • neutrophil: 23 nTPM
  • basophil: 11 nTPM
  • non-classical monocyte: 11 nTPM
  • naive B-cell: 11 nTPM
  • T-reg: 10 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • cerebellum: 26 nTPM
  • medulla oblongata: 25 nTPM
  • thalamus: 24 nTPM
  • white matter: 23 nTPM
  • amygdala: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.17
gnomAD missense Z
0.78
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRR14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR14 as an antibody target. Whether an autoantibody or antibody against PRR14 could matter depends on whether native PRR14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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