Seroatlas · Human Serome Atlas

STRIP1

Striatin-interacting protein 1

Also known as: FAM40A, FAR11A, FLJ14743, KIAA1761, STRP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VSL9
Gene: STRIP1
Ensembl: ENSG00000143093
Chromosome: 1
Canonical length: 837 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

837 residues, UniProt reviewed canonical sequence.

>Q5VSL9|STRIP1
     1  MEPAVGGPGP LIVNNKQPQP PPPPPPAAAQ PPPGAPRAAA GLLPGGKARE FNRNQRKDSE
    61  GYSESPDLEF EYADTDKWAA ELSELYSYTE GPEFLMNRKC FEEDFRIHVT DKKWTELDTN
   121  QHRTHAMRLL DGLEVTAREK RLKVARAILY VAQGTFGECS SEAEVQSWMR YNIFLLLEVG
   181  TFNALVELLN MEIDNSAACS SAVRKPAISL ADSTDLRVLL NIMYLIVETV HQECEGDKAE
   241  WRTMRQTFRA ELGSPLYNNE PFAIMLFGMV TKFCSGHAPH FPMKKVLLLL WKTVLCTLGG
   301  FEELQSMKAE KRSILGLPPL PEDSIKVIRN MRAASPPASA SDLIEQQQKR GRREHKALIK
   361  QDNLDAFNER DPYKADDSRE EEEENDDDNS LEGETFPLER DEVMPPPLQH PQTDRLTCPK
   421  GLPWAPKVRE KDIEMFLESS RSKFIGYTLG SDTNTVVGLP RPIHESIKTL KQHKYTSIAE
   481  VQAQMEEEYL RSPLSGGEEE VEQVPAETLY QGLLPSLPQY MIALLKILLA AAPTSKAKTD
   541  SINILADVLP EEMPTTVLQS MKLGVDVNRH KEVIVKAISA VLLLLLKHFK LNHVYQFEYM
   601  AQHLVFANCI PLILKFFNQN IMSYITAKNS ISVLDYPHCV VHELPELTAE SLEAGDSNQF
   661  CWRNLFSCIN LLRILNKLTK WKHSRTMMLV VFKSAPILKR ALKVKQAMMQ LYVLKLLKVQ
   721  TKYLGRQWRK SNMKTMSAIY QKVRHRLNDD WAYGNDLDAR PWDFQAEECA LRANIERFNA
   781  RRYDRAHSNP DFLPVDNCLQ SVLGQRVDLP EDFQMNYDLW LEREVFSKPI SWEELLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 26 nTPM
spleen: 22 nTPM
bone marrow: 21 nTPM
cerebral cortex: 21 nTPM
parathyroid gland: 20 nTPM
small intestine: 19 nTPM

Single-cell type

late spermatids: 83 nCPM
early spermatids: 67 nCPM
endometrial luminal cells: 42 nCPM
syncytiotrophoblasts: 37 nCPM
lactotrophs: 30 nCPM
neutrophil progenitors: 30 nCPM

Immune cell

NK-cell: 16 nTPM
memory CD8 T-cell: 16 nTPM
non-classical monocyte: 16 nTPM
eosinophil: 15 nTPM
gdT-cell: 15 nTPM
naive CD4 T-cell: 14 nTPM

Brain region

thalamus: 36 nTPM
cerebral cortex: 29 nTPM
pons: 29 nTPM
basal ganglia: 28 nTPM
hypothalamus: 28 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 2.38
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRIP1 as an antibody target. Whether an autoantibody or antibody against STRIP1 could matter depends on whether native STRIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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