Seroatlas · Human Serome Atlas

GRIN3A

Glutamate receptor ionotropic, NMDA 3A

Also known as: GluN3A, NMD3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TCU5
Gene
GRIN3A
Ensembl
ENSG00000198785
Chromosome
9
Canonical length
1115 aa
Protein class
FDA approved drug targets, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1115 residues, UniProt reviewed canonical sequence.

>Q8TCU5|GRIN3A
     1  MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV GAVHLQPWTT
    61  APRAASRAPD DSRAGAQRDE PEPGTRRSPA PSPGARWLGS TLHGRGPPGS RKPGEGARAE
   121  ALWPRDALLF AVDNLNRVEG LLPYNLSLEV VMAIEAGLGD LPLLPFSSPS SPWSSDPFSF
   181  LQSVCHTVVV QGVSALLAFP QSQGEMMELD LVSLVLHIPV ISIVRHEFPR ESQNPLHLQL
   241  SLENSLSSDA DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTQNNSKFH LGSIINITAN
   301  LPSTQDLLSF LQIQLESIKN STPTVVMFGC DMESIRRIFE ITTQFGVMPP ELRWVLGDSQ
   361  NVEELRTEGL PLGLIAHGKT TQSVFEHYVQ DAMELVARAV ATATMIQPEL ALIPSTMNCM
   421  EVETTNLTSG QYLSRFLANT TFRGLSGSIR VKGSTIVSSE NNFFIWNLQH DPMGKPMWTR
   481  LGSWQGGKIV MDYGIWPEQA QRHKTHFQHP SKLHLRVVTL IEHPFVFTRE VDDEGLCPAG
   541  QLCLDPMTND SSTLDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEKIAED MNFDFDLYIV
   601  GDGKYGAWKN GHWTGLVGDL LRGTAHMAVT SFSINTARSQ VIDFTSPFFS TSLGILVRTR
   661  DTAAPIGAFM WPLHWTMWLG IFVALHITAV FLTLYEWKSP FGLTPKGRNR SKVFSFSSAL
   721  NICYALLFGR TVAIKPPKCW TGRFLMNLWA IFCMFCLSTY TANLAAVMVG EKIYEELSGI
   781  HDPKLHHPSQ GFRFGTVRES SAEDYVRQSF PEMHEYMRRY NVPATPDGVE YLKNDPEKLD
   841  AFIMDKALLD YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTANISEL ISQYKSHGFM
   901  DMLHDKWYRV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI GEHIVYRLLL
   961  PRIKNKSKLQ YWLHTSQRLH RAINTSFIEE KQQHFKTKRV EKRSNVGPRQ LTVWNTSNLS
  1021  HDNRRKYIFS DEEGQNQLGI RIHQDIPLPP RRRELPALRT TNGKADSLNV SRNSVMQELS
  1081  ELEKQIQVIR QELQLAVSRK TELEEYQRTS RTCES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRIN3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
7.1 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 7.1 nTPM
  • hypothalamus: 1.8 nTPM
  • cervix: 1.4 nTPM
  • amygdala: 1.1 nTPM
  • midbrain: 1 nTPM
  • hippocampal formation: 0.9 nTPM

Single-cell type

  • brain inhibitory neurons: 108 nCPM
  • brain excitatory neurons: 49 nCPM
  • other brain neurons: 48 nCPM
  • retinal amacrine cells: 23 nCPM
  • prostatic glandular cells: 19 nCPM
  • epicardial cells: 14 nCPM

Immune cell

  • intermediate monocyte: 0.8 nTPM
  • non-classical monocyte: 0.7 nTPM
  • classical monocyte: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • hypothalamus: 17 nTPM
  • basal ganglia: 14 nTPM
  • cerebral cortex: 14 nTPM
  • thalamus: 11 nTPM
  • midbrain: 9 nTPM
  • pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.45
gnomAD missense Z
0.74
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRIN3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRIN3A as an antibody target. Whether an autoantibody or antibody against GRIN3A could matter depends on whether native GRIN3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRIN3A is annotated at the cell surface, where native GRIN3A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GRIN3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRIN3A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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