Seroatlas · Human Serome Atlas

MRPS2

Small ribosomal subunit protein uS2m

Also known as: CGI-91, RT02_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y399
Gene
MRPS2
Ensembl
ENSG00000122140
Chromosome
9
Canonical length
296 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q9Y399|MRPS2
     1  MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR ESEDSTDFND
    61  KILNEPLKHS DFFNVKELFS VRSLFDARVH LGHKAGCRHR FMEPYIFGSR LDHDIIDLEQ
   121  TATHLQLALN FTAHMAYRKG IILFISRNRQ FSYLIENMAR DCGEYAHTRY FRGGMLTNAR
   181  LLFGPTVRLP DLIIFLHTLN NIFEPHVAVR DAAKMNIPTV GIVDTNCNPC LITYPVPGND
   241  DSPLAVHLYC RLFQTAITRA KEKRQQVEAL YRLQGQKEPG DQGPAHPPGA DMSHSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • liver: 79 nTPM
  • skeletal muscle: 74 nTPM
  • heart muscle: 66 nTPM
  • adrenal gland: 56 nTPM
  • tongue: 47 nTPM
  • kidney: 45 nTPM

Single-cell type

  • migrating cytotrophoblasts: 109 nCPM
  • esophageal basal cells: 109 nCPM
  • endometrial glandular cells: 106 nCPM
  • fallopian secretory cells: 94 nCPM
  • cytotrophoblasts: 82 nCPM
  • decidual stromal cells: 75 nCPM

Immune cell

  • T-reg: 38 nTPM
  • MAIT T-cell: 32 nTPM
  • memory B-cell: 32 nTPM
  • naive B-cell: 32 nTPM
  • memory CD8 T-cell: 31 nTPM
  • naive CD8 T-cell: 30 nTPM

Brain region

  • choroid plexus: 29 nTPM
  • thalamus: 24 nTPM
  • cerebral cortex: 22 nTPM
  • midbrain: 20 nTPM
  • pons: 19 nTPM
  • hypothalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPS2.

Disease | AllUniProt

Conditions MRPS2 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 36 (COXPD36) MIM:617950

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Combined oxidative phosphorylation deficiency 36

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.86
gnomAD pLI
0
gnomAD missense Z
0.07
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS2 as an antibody target. Whether an autoantibody or antibody against MRPS2 could matter depends on whether native MRPS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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