Seroatlas · Human Serome Atlas

MRPS6

Small ribosomal subunit protein bS6m

Also known as: C21orf101, MRP-S6, RPMS6, RT06_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P82932
Gene
MRPS6
Ensembl
ENSG00000243927
Chromosome
21
Canonical length
125 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>P82932|MRPS6
     1  MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR ISAHSQQHNR
    61  GGYFLVDFYA PTAAVESMVE HLSRDIDVIR GNIVKHPLTQ ELKECEGIVP VPLAEKLYST
   121  KKRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
320 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 320 nTPM
  • kidney: 308 nTPM
  • blood vessel: 122 nTPM
  • thyroid gland: 102 nTPM
  • skeletal muscle: 99 nTPM
  • colon: 83 nTPM

Single-cell type

  • loop of henle epithelial cells: 485 nCPM
  • distal convoluted tubule cells: 341 nCPM
  • renal collecting duct principal cells: 291 nCPM
  • renal collecting duct intercalated cells: 236 nCPM
  • papillary tip epithelial cells: 132 nCPM
  • renal connecting tubule cells: 109 nCPM

Immune cell

  • NK-cell: 116 nTPM
  • plasmacytoid DC: 102 nTPM
  • gdT-cell: 91 nTPM
  • naive CD8 T-cell: 88 nTPM
  • naive CD4 T-cell: 84 nTPM
  • memory CD8 T-cell: 81 nTPM

Brain region

  • choroid plexus: 93 nTPM
  • hypothalamus: 44 nTPM
  • spinal cord: 36 nTPM
  • white matter: 32 nTPM
  • midbrain: 31 nTPM
  • basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
-0.26
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS6 as an antibody target. Whether an autoantibody or antibody against MRPS6 could matter depends on whether native MRPS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPS6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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