Seroatlas · Human Serome Atlas

MRPS24

Small ribosomal subunit protein uS3m

Also known as: HSPC335, MRP-S24, RT24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EL2
Gene
MRPS24
Ensembl
ENSG00000062582
Chromosome
7
Canonical length
167 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q96EL2|MRPS24
     1  MAASVCSGLL GPRVLSWSRE LPCAWRALHT SPVCAKNRAA RVRVSKGDKP VTYEEAHAPH
    61  YIAHRKGWLS LHTGNLDGED HAAERTVEDV FLRKFMWGTF PGCLADQLVL KRRGNQLEIC
   121  AVVLRQLSPH KYYFLVGYSE TLLSYFYKCP VRLHLQTVPS KVVYKYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
427 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 427 nTPM
  • tongue: 262 nTPM
  • heart muscle: 237 nTPM
  • liver: 179 nTPM
  • kidney: 176 nTPM
  • adrenal gland: 166 nTPM

Single-cell type

  • other brain neurons: 25 nCPM
  • brain excitatory neurons: 20 nCPM
  • hepatocytes: 19 nCPM
  • brain inhibitory neurons: 18 nCPM
  • parietal cells: 18 nCPM
  • ependymal cells: 15 nCPM

Immune cell

  • myeloid DC: 242 nTPM
  • memory B-cell: 224 nTPM
  • T-reg: 215 nTPM
  • naive B-cell: 197 nTPM
  • intermediate monocyte: 182 nTPM
  • non-classical monocyte: 182 nTPM

Brain region

  • thalamus: 73 nTPM
  • hypothalamus: 68 nTPM
  • choroid plexus: 67 nTPM
  • cerebellum: 67 nTPM
  • cerebral cortex: 60 nTPM
  • amygdala: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
0.09
DepMap mean gene effect
-0.37
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small ribosomal subunit protein uS3m, metazoan
  • Mitochondrial ribosome subunit S24

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS24 as an antibody target. Whether an autoantibody or antibody against MRPS24 could matter depends on whether native MRPS24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPS24. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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