MRPS34

Protein identityUniProt · HPA

UniProt accession

P82930

Gene

MRPS34

Ensembl

ENSG00000074071

Chromosome

16

Canonical length

218 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>P82930|MRPS34
     1  MARKKVRPRL IAELARRVRA LREQLNRPRD SQLYAVDYET LTRPFSGRRL PVRAWADVRR
    61  ESRLLQLLGR LPLFGLGRLV TRKSWLWQHD EPCYWRLTRV RPDYTAQNLD HGKAWGILTF
   121  KGKTESEARE IEHVMYHDWR LVPKHEEEAF TAFTPAPEDS LASVPYPPLL RAMIIAERQK
   181  NGDTSTEEPM LNVQRIRMEP WDYPAKQEDK GRAKGTPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

90 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPS34.

Disease | AllUniProt

Conditions MRPS34 is implicated in, by any mechanism.

• Combined oxidative phosphorylation deficiency 32 (COXPD32) MIM:617664

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Combined oxidative phosphorylation deficiency 32
• Leigh syndrome
• Inborn genetic diseases
• Ovarian serous cystadenocarcinoma
• MRPS34-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.72

gnomAD pLI

0

gnomAD missense Z

-1.43

DepMap mean gene effect

-0.53

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation

Molecular functions

• structural constituent of ribosome

Cellular components

• mitochondrial inner membrane
• mitochondrial small ribosomal subunit
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein mS34
• Mitochondrial 28S ribosomal protein S34

KeywordsUniProt

• Mitochondrion
• Primary mitochondrial disease
• Ribonucleoprotein
• Ribosomal protein

InteractionsUniProt · HPA

Protein binding partners of MRPS34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AURKAIP1
• CTCF
• MRPS12
• MRPS14
• MRPS17
• MRPS22
• MRPS23
• MRPS25
• MRPS26
• MRPS27
• PSME3