Seroatlas · Human Serome Atlas

MRPL18

Large ribosomal subunit protein uL18m

Also known as: HSPC071, RM18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0U6
Gene: MRPL18
Ensembl: ENSG00000112110
Chromosome: 6
Canonical length: 180 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>Q9H0U6|MRPL18
     1  MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN RNPRNLELLS
    61  VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK VVVSASTREW AIKKHLYSTR
   121  NVVACESIGR VLAQRCLEAG INFMVYQPTP WEAASDSMKR LQSAMTEGGV VLREPQRIYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 73 nTPM
tongue: 69 nTPM
cerebral cortex: 62 nTPM
liver: 62 nTPM
heart muscle: 61 nTPM
amygdala: 60 nTPM

Single-cell type

pancreatic duct cells: 489 nCPM
oocytes: 295 nCPM
early primary spermatocytes: 263 nCPM
epididymal principal cells: 251 nCPM
epididymal efferent duct absorptive cells: 239 nCPM
megakaryocytes: 235 nCPM

Immune cell

total PBMC: 193 nTPM
non-classical monocyte: 177 nTPM
plasmacytoid DC: 168 nTPM
memory B-cell: 155 nTPM
intermediate monocyte: 153 nTPM
T-reg: 138 nTPM

Brain region

cerebral cortex: 60 nTPM
white matter: 46 nTPM
cerebellum: 40 nTPM
hypothalamus: 38 nTPM
basal ganglia: 37 nTPM
spinal cord: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: -0.39
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein uS11 superfamily
Large ribosomal subunit protein uL18
Large ribosomal subunit protein uL18, bacterial/plantae/animalia
Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL18 as an antibody target. Whether an autoantibody or antibody against MRPL18 could matter depends on whether native MRPL18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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