Seroatlas · Human Serome Atlas

MRPS22

Small ribosomal subunit protein mS22

Also known as: C3orf5, GIBT, GK002, MRP-S22, RT22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P82650
Gene
MRPS22
Ensembl
ENSG00000175110
Chromosome
3
Canonical length
360 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>P82650|MRPS22
     1  MAPLGTTVLL WSLLRSSPGV ERVCFRARIQ PWHGGLLQPL PCSFEMGLPR RRFSSEAAES
    61  GSPETKKPTF MDEEVQSILT KMTGLNLQKT FKPAIQELKP PTYKLMTQAQ LEEATRQAVE
   121  AAKVRLKMPP VLEERVPIND VLAEDKILEG TETTKYVFTD ISYSIPHRER FIVVREPSGT
   181  LRKASWEERD RMIQVYFPKE GRKILTPIIF KEENLRTMYS QDRHVDVLNL CFAQFEPDST
   241  EYIKVHHKTY EDIDKRGKYD LLRSTRYFGG MVWYFVNNKK IDGLLIDQIQ RDLIDDATNL
   301  VQLYHVLHPD GQSAQGAKDQ AAEGINLIKV FAKTEAQKGA YIELTLQTYQ EALSRHSAAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 73 nTPM
  • tongue: 73 nTPM
  • heart muscle: 57 nTPM
  • adrenal gland: 54 nTPM
  • liver: 51 nTPM
  • bone marrow: 38 nTPM

Single-cell type

  • late primary spermatocytes: 236 nCPM
  • esophageal suprabasal cells: 134 nCPM
  • oocytes: 134 nCPM
  • esophageal basal cells: 110 nCPM
  • gonadotrophs: 104 nCPM
  • esophageal apical cells: 99 nCPM

Immune cell

  • non-classical monocyte: 52 nTPM
  • intermediate monocyte: 52 nTPM
  • T-reg: 46 nTPM
  • myeloid DC: 45 nTPM
  • basophil: 42 nTPM
  • MAIT T-cell: 41 nTPM

Brain region

  • hypothalamus: 26 nTPM
  • white matter: 25 nTPM
  • cerebellum: 25 nTPM
  • cerebral cortex: 24 nTPM
  • pons: 24 nTPM
  • spinal cord: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPS22.

Disease | AllUniProt

Conditions MRPS22 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 5 (COXPD5) MIM:611719
  • Ovarian dysgenesis 7 (ODG7) MIM:618117

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 236 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
-0.55
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small ribosomal subunit protein mS22
  • Mitochondrial 28S ribosomal protein S22

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS22 as an antibody target. Whether an autoantibody or antibody against MRPS22 could matter depends on whether native MRPS22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPS22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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