MRPS16

Protein identityUniProt · HPA

UniProt accession

Q9Y3D3

Gene

MRPS16

Ensembl

ENSG00000182180

Chromosome

10

Canonical length

137 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Mitochondria,Cytosol

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>Q9Y3D3|MRPS16
     1  MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ LGSYDPLPNS
    61  HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH PMMITNAERL RRKRAREVLL
   121  ASQKTDAEAT DTEATET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

73 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPS16.

Disease | AllUniProt

Conditions MRPS16 is implicated in, by any mechanism.

• Combined oxidative phosphorylation deficiency 2 (COXPD2) MIM:610498

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 108 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Combined oxidative phosphorylation defect type 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.59

gnomAD pLI

0.06

gnomAD missense Z

-0.55

DepMap mean gene effect

-0.5

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation
• translation

Molecular functions

• structural constituent of ribosome

Cellular components

• cytosol
• mitochondrial inner membrane
• mitochondrial small ribosomal subunit
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein bS16
• Small ribosomal subunit protein bS16 domain superfamily
• Ribosomal protein S16

KeywordsUniProt

• Mitochondrion
• Phosphoprotein
• Primary mitochondrial disease
• Ribonucleoprotein
• Ribosomal protein
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of MRPS16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AURKAIP1
• MCAT
• MRPS2
• MRPS23
• MRPS24
• MRPS25
• MRPS26
• MRPS27
• MRPS31
• MRPS9