MRPS5

Protein identityUniProt · HPA

UniProt accession

P82675

Gene

MRPS5

Ensembl

ENSG00000144029

Chromosome

2

Canonical length

430 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>P82675|MRPS5
     1  MATAVRAVGC LPVLCSGTAG HLLGRQCSLN TLPAASILAW KSVLGNGHLS SLGTRDTHPY
    61  ASLSRALQTQ CCISSPSHLM SQQYRPYSFF TKLTADELWK GALAETGAGA KKGRGKRTKK
   121  KKRKDLNRGQ IIGEGRYGFL WPGLNVPLMK NGAVQTIAQR SKEEQEKVEA DMIQQREEWD
   181  RKKKMKVKRE RGWSGNSWGG ISLGPPDPGP CGETYEDFDT RILEVRNVFT MTAKEGRKKS
   241  IRVLVAVGNG KGAAGFSIGK ATDRMDAFRK AKNRAVHHLH YIERYEDHTI FHDISLRFKR
   301  THIKMKKQPK GYGLRCHRAI ITICRLIGIK DMYAKVSGSI NMLSLTQGLF RGLSRQETHQ
   361  QLADKKGLHV VEIREECGPL PIVVASPRGP LRKDPEPEDE VPDVKLDWED VKTAQGMKRS
   421  VWSNLKRAAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0

gnomAD missense Z

0.33

DepMap mean gene effect

-0.75

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation
• translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• mitochondrial inner membrane
• mitochondrial small ribosomal subunit
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein uS5
• Small ribosomal subunit protein uS5, C-terminal
• Small ribosomal subunit protein uS5, N-terminal
• Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
• Small ribosomal subunit protein uS5, N-terminal, conserved site
• Ribosomal protein uS5 domain 2-type superfamily
• Ribosomal protein S5, N-terminal domain
• Ribosomal protein S5, C-terminal domain
• Small ribosomal subunit protein uS5m, N-terminal domain
• Small ribosomal subunit protein uS5m, N-terminal

KeywordsUniProt

• Mitochondrion
• Ribonucleoprotein
• Ribosomal protein

InteractionsUniProt · HPA

Protein binding partners of MRPS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AURKAIP1
• MRPS26
• RPL17
• ZC3HAV1