Seroatlas · Human Serome Atlas

MRPS7

Small ribosomal subunit protein uS7m

Also known as: MRP-S, RP-S7, RPMS7, RT07_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2R9
Gene
MRPS7
Ensembl
ENSG00000125445
Chromosome
17
Canonical length
242 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q9Y2R9|MRPS7
     1  MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY YRKPVEELTE
    61  EEKYVRELKK TQLIKAAPAG KTSSVFEDPV ISKFTNMMMI GGNKVLARSL MIQTLEAVKR
   121  KQFEKYHAAS AEEQATIERN PYTIFHQALK NCEPMIGLVP ILKGGRFYQV PVPLPDRRRR
   181  FLAMKWMITE CRDKKHQRTL MPEKLSHKLL EAFHNQGPVI KRKHDLHKMA EANRALAHYR
   241  WW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
198 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 198 nTPM
  • skeletal muscle: 191 nTPM
  • heart muscle: 156 nTPM
  • choroid plexus: 91 nTPM
  • kidney: 86 nTPM
  • liver: 79 nTPM

Single-cell type

  • late spermatids: 846 nCPM
  • esophageal suprabasal cells: 240 nCPM
  • cytotrophoblasts: 231 nCPM
  • migrating cytotrophoblasts: 223 nCPM
  • esophageal basal cells: 221 nCPM
  • extravillous trophoblasts: 195 nCPM

Immune cell

  • total PBMC: 236 nTPM
  • myeloid DC: 172 nTPM
  • plasmacytoid DC: 165 nTPM
  • intermediate monocyte: 162 nTPM
  • classical monocyte: 155 nTPM
  • T-reg: 142 nTPM

Brain region

  • thalamus: 43 nTPM
  • cerebellum: 42 nTPM
  • hypothalamus: 41 nTPM
  • choroid plexus: 41 nTPM
  • spinal cord: 38 nTPM
  • midbrain: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPS7.

Disease | AllUniProt

Conditions MRPS7 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 34 (COXPD34) MIM:617872

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-0.08
DepMap mean gene effect
-0.44
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS7 as an antibody target. Whether an autoantibody or antibody against MRPS7 could matter depends on whether native MRPS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MRPS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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