Seroatlas · Human Serome Atlas

PTCD3

Small ribosomal subunit protein mS39

Also known as: DKFZp666K071, FLJ20758, PTCD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EY7
Gene
PTCD3
Ensembl
ENSG00000132300
Chromosome
2
Canonical length
689 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables rRNA binding activity and ribosomal small subunit binding activity. Involved in mitochondrial translation. Located in several cellular components, including cytosol; mitochondrial matrix; and nucleoplasm. Implicated in combined oxidative phosphorylation deficiency 51. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

689 residues, UniProt reviewed canonical sequence.

>Q96EY7|PTCD3
     1  MAVVSAVRWL GLRSRLGQPL TGRRAGLCEQ ARSCRFYSGS ATLSKVEGTD VTGIEEVVIP
    61  KKKTWDKVAV LQALASTVNR DTTAVPYVFQ DDPYLMPASS LESRSFLLAK KSGENVAKFI
   121  INSYPKYFQK DIAEPHIPCL MPEYFEPQIK DISEAALKER IELRKVKASV DMFDQLLQAG
   181  TTVSLETTNS LLDLLCYYGD QEPSTDYHFQ QTGQSEALEE ENDETSRRKA GHQFGVTWRA
   241  KNNAERIFSL MPEKNEHSYC TMIRGMVKHR AYEQALNLYT ELLNNRLHAD VYTFNALIEA
   301  TVCAINEKFE EKWSKILELL RHMVAQKVKP NLQTFNTILK CLRRFHVFAR SPALQVLREM
   361  KAIGIEPSLA TYHHIIRLFD QPGDPLKRSS FIIYDIMNEL MGKRFSPKDP DDDKFFQSAM
   421  SICSSLRDLE LAYQVHGLLK TGDNWKFIGP DQHRNFYYSK FFDLICLMEQ IDVTLKWYED
   481  LIPSAYFPHS QTMIHLLQAL DVANRLEVIP KIWKDSKEYG HTFRSDLREE ILMLMARDKH
   541  PPELQVAFAD CAADIKSAYE SQPIRQTAQD WPATSLNCIA ILFLRAGRTQ EAWKMLGLFR
   601  KHNKIPRSEL LNELMDSAKV SNSPSQAIEV VELASAFSLP ICEGLTQRVM SDFAINQEQK
   661  EALSNLTALT SDSDTDSSSD SDSDTSEGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTCD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 34 nTPM
  • skeletal muscle: 31 nTPM
  • heart muscle: 25 nTPM
  • choroid plexus: 18 nTPM
  • liver: 16 nTPM
  • testis: 16 nTPM

Single-cell type

  • myonuclei: 150 nCPM
  • erythrocyte progenitors: 144 nCPM
  • oocytes: 129 nCPM
  • adrenal cortex cells: 105 nCPM
  • late primary spermatocytes: 104 nCPM
  • choroid plexus epithelial cells: 99 nCPM

Immune cell

  • naive B-cell: 17 nTPM
  • memory B-cell: 16 nTPM
  • naive CD4 T-cell: 15 nTPM
  • MAIT T-cell: 15 nTPM
  • NK-cell: 14 nTPM
  • non-classical monocyte: 14 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • white matter: 27 nTPM
  • cerebellum: 24 nTPM
  • pons: 23 nTPM
  • hypothalamus: 23 nTPM
  • cerebral cortex: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTCD3.

Disease | AllUniProt

Conditions PTCD3 is implicated in, by any mechanism.

  • Combined oxidative phosphorylation deficiency 51 (COXPD51) MIM:619057

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Combined oxidative phosphorylation deficiency 51
  • PTCD3-related disorder
  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.48
DepMap mean gene effect
-0.71
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTCD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTCD3 as an antibody target. Whether an autoantibody or antibody against PTCD3 could matter depends on whether native PTCD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTCD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTCD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTCD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...