Seroatlas · Human Serome Atlas

MRPS17

Small ribosomal subunit protein uS17m

Also known as: HSPC011, MRP-S17, RPMS17, RT17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2R5
Gene: MRPS17
Ensembl: ENSG00000239789
Chromosome: 7
Canonical length: 130 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>Q9Y2R5|MRPS17
     1  MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF AHDALQQCTV
    61  GDIVLLRALP VPRAKHVKHE LAEIVFKVGK VIDPVTGKPC AGTTYLESPL SSETTQLSKN
   121  LEELNISSAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
tongue: 30 nTPM
liver: 21 nTPM
heart muscle: 19 nTPM
cerebral cortex: 16 nTPM
kidney: 14 nTPM

Single-cell type

parietal cells: 27 nCPM
gastric chief cells: 16 nCPM
late primary spermatocytes: 12 nCPM
hepatocytes: 11 nCPM
endometrial secretory cells: 8.4 nCPM
endometrial ciliated cells: 7.4 nCPM

Immune cell

memory B-cell: 17 nTPM
naive CD4 T-cell: 16 nTPM
T-reg: 16 nTPM
memory CD8 T-cell: 15 nTPM
memory CD4 T-cell: 14 nTPM
naive B-cell: 14 nTPM

Brain region

hypothalamus: 20 nTPM
cerebral cortex: 19 nTPM
hippocampal formation: 19 nTPM
basal ganglia: 17 nTPM
pons: 17 nTPM
cerebellum: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 22% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein uS17
Nucleic acid-binding, OB-fold
Ribosomal protein S17
Small ribosomal subunit protein uS17m, metazoa

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPS17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPS17 as an antibody target. Whether an autoantibody or antibody against MRPS17 could matter depends on whether native MRPS17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPS17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPS17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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