AURKAIP1
Small ribosomal subunit protein mS38
Also known as: AIP, AKIP, AKIP_HUMAN, FLJ20608
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NWT8
- Gene
- AURKAIP1
- Ensembl
- ENSG00000175756
- Chromosome
- 1
- Canonical length
- 199 aa
- Protein class
- Predicted intracellular proteins, Ribosomal proteins
- Subcellular location
- Nucleoplasm,Mitochondria
OverviewNCBI Gene
Acts upstream of or within positive regulation of proteolysis. Located in mitochondrial matrix and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
199 residues, UniProt reviewed canonical sequence.
>Q9NWT8|AURKAIP1
1 MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS LPRKGAQLEL
61 EEMLVPRKMS VSPLESWLTA RCFLPRLDTG TAGTVAPPQS YQCPPSQIGE GAEQGDEGVA
121 DAPQIQCKNV LKIRRRKMNH HKYRKLVKKT RFLRRKVQEG RLRRKQIKFE KDLRRIWLKA
181 GLKEAPEGWQ TPKIYLRGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against AURKAIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 324 nTPM
Expression across tissuesHPA
Tissue
- testis: 324 nTPM
- skeletal muscle: 310 nTPM
- heart muscle: 292 nTPM
- liver: 247 nTPM
- choroid plexus: 213 nTPM
- kidney: 198 nTPM
Single-cell type
- late spermatids: 5,716 nCPM
- late primary spermatocytes: 1,445 nCPM
- early spermatids: 1,256 nCPM
- esophageal suprabasal cells: 650 nCPM
- esophageal apical cells: 642 nCPM
- colonocytes: 585 nCPM
Immune cell
- plasmacytoid DC: 351 nTPM
- neutrophil: 337 nTPM
- basophil: 324 nTPM
- eosinophil: 314 nTPM
- T-reg: 274 nTPM
- classical monocyte: 273 nTPM
Brain region
- choroid plexus: 133 nTPM
- thalamus: 129 nTPM
- cerebellum: 119 nTPM
- medulla oblongata: 119 nTPM
- spinal cord: 102 nTPM
- midbrain: 101 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.77
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- -0.43
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Ribosomal protein bS22, C-terminal
- Mitochondrial mRNA-processing protein COX24, C-terminal
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of AURKAIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads AURKAIP1 as an antibody target. Whether an autoantibody or antibody against AURKAIP1 could matter depends on whether native AURKAIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
AURKAIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label AURKAIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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