MRPS14

Protein identityUniProt · HPA

UniProt accession

O60783

Gene

MRPS14

Ensembl

ENSG00000120333

Chromosome

1

Canonical length

128 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Nuclear membrane,Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>O60783|MRPS14
     1  MAAFMLGSLL RTFKQMVPSS ASGQVRSHYV DWRMWRDVKR RKMAYEYADE RLRINSLRKN
    61  TILPKILQDV ADEEIAALPR DSCPVRIRNR CVMTSRPRGV KRRWRLSRIV FRHLADHGQL
   121  SGIQRATW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPS14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

29 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPS14.

Disease | AllUniProt

Conditions MRPS14 is implicated in, by any mechanism.

• Combined oxidative phosphorylation deficiency 38 (COXPD38) MIM:618378

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Combined oxidative phosphorylation deficiency 38

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.66

gnomAD pLI

0

gnomAD missense Z

0.35

DepMap mean gene effect

-0.59

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation
• translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• mitochondrial inner membrane
• mitochondrial ribosome
• mitochondrial small ribosomal subunit
• mitochondrion
• nuclear membrane

Protein domainsUniProt · Pfam · InterPro

• Small ribosomal subunit protein uS14
• Ribosomal protein S14p/S29e

KeywordsUniProt

• Mitochondrion
• Primary mitochondrial disease
• Ribonucleoprotein
• Ribosomal protein

InteractionsUniProt · HPA

Protein binding partners of MRPS14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LIAT1
• AURKAIP1
• MRPS17
• MRPS2
• MRPS23
• MRPS24
• MRPS26
• MRPS31
• MRPS34
• MRPS7