Seroatlas · Human Serome Atlas

FERMT2

Fermitin family homolog 2

Also known as: FERM2_HUMAN, KIND2, mig-2, PLEKHC1, UNC112B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96AC1
Gene
FERMT2
Ensembl
ENSG00000073712
Chromosome
14
Canonical length
680 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Focal adhesion sites,Cytosol

OverviewNCBI Gene

Enables several functions, including phosphatidylinositol-3,4,5-trisphosphate binding activity; protein serine/threonine kinase binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and positive regulation of intracellular signal transduction. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in several cellular components, including adherens junction; cytoplasmic side of plasma membrane; and focal adhesion. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

680 residues, UniProt reviewed canonical sequence.

>Q96AC1|FERMT2
     1  MALDGIRMPD GCYADGTWEL SVHVTDLNRD VTLRVTGEVH IGGVMLKLVE KLDVKKDWSD
    61  HALWWEKKRT WLLKTHWTLD KYGIQADAKL QFTPQHKLLR LQLPNMKYVK VKVNFSDRVF
   121  KAVSDICKTF NIRHPEELSL LKKPRDPTKK KKKKLDDQSE DEALELEGPL ITPGSGSIYS
   181  SPGLYSKTMT PTYDAHDGSP LSPTSAWFGD SALSEGNPGI LAVSQPITSP EILAKMFKPQ
   241  ALLDKAKINQ GWLDSSRSLM EQDVKENEAL LLRFKYYSFF DLNPKYDAIR INQLYEQAKW
   301  AILLEEIECT EEEMMMFAAL QYHINKLSIM TSENHLNNSD KEVDEVDAAL SDLEITLEGG
   361  KTSTILGDIT SIPELADYIK VFKPKKLTLK GYKQYWCTFK DTSISCYKSK EESSGTPAHQ
   421  MNLRGCEVTP DVNISGQKFN IKLLIPVAEG MNEIWLRCDN EKQYAHWMAA CRLASKGKTM
   481  ADSSYNLEVQ NILSFLKMQH LNPDPQLIPE QITTDITPEC LVSPRYLKKY KNKQITARIL
   541  EAHQNVAQMS LIEAKMRFIQ AWQSLPEFGI THFIARFQGG KKEELIGIAY NRLIRMDAST
   601  GDAIKTWRFS NMKQWNVNWE IKMVTVEFAD EVRLSFICTE VDCKVVHEFI GGYIFLSTRA
   661  KDQNESLDEE MFYKLTSGWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FERMT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
145 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 145 nTPM
  • blood vessel: 142 nTPM
  • adipose tissue: 139 nTPM
  • seminal vesicle: 111 nTPM
  • placenta: 109 nTPM
  • liver: 101 nTPM

Single-cell type

  • smooth muscle cells: 537 nCPM
  • adipocytes: 420 nCPM
  • podocytes: 360 nCPM
  • extravillous trophoblasts: 347 nCPM
  • salivary myoepithelial cells: 344 nCPM
  • decidual stromal cells: 335 nCPM

Immune cell

  • MAIT T-cell: 0.9 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 66 nTPM
  • medulla oblongata: 65 nTPM
  • cerebral cortex: 60 nTPM
  • basal ganglia: 54 nTPM
  • hippocampal formation: 53 nTPM
  • spinal cord: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
1.96
DepMap mean gene effect
-0.61
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FERMT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FERMT2 as an antibody target. Whether an autoantibody or antibody against FERMT2 could matter depends on whether native FERMT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FERMT2 is annotated at the cell surface, where native FERMT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FERMT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FERMT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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