PSI domain
IPR016201
Definition
This domain is found in several different extracellular receptors, including plexins, which are involved in the development of neural and epithelial tissues PMID:17855350; in semaphorins, which regulate axon guidance, immune function and angiogenesis PMID:12958590; in integrins, which are important Metazoan adhesion receptors that transmit conformational change bidirectionally across the membrane (integrin alpha and beta subunits form a head and two long legs in the ectodomain and span the membrane) PMID:15378069; and in hepatocyte growth factor receptor, which plays important roles in normal development and in tumour growth and metastasis PMID:15167892.
42 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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