Seroatlas · Human Serome Atlas

EMP2

Epithelial membrane protein 2

Also known as: EMP2_HUMAN, XMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54851
Gene
EMP2
Ensembl
ENSG00000213853
Chromosome
16
Canonical length
167 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>P54851|EMP2
     1  MLVLLAFIIA FHITSAALLF IATVDNAWWV GDEFFADVWR ICTNNTNCTV INDSFQEYST
    61  LQAVQATMIL STILCCIAFF IFVLQLFRLK QGERFVLTSI IQLMSCLCVM IAASIYTDRR
   121  EDIHDKNAKF YPVTREGSYG YSYILAWVAF ACTFISGMMY LILRKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
215 nTPM

Expression across tissuesHPA

Tissue

  • lung: 215 nTPM
  • esophagus: 134 nTPM
  • skin: 132 nTPM
  • blood vessel: 78 nTPM
  • liver: 77 nTPM
  • vagina: 66 nTPM

Single-cell type

  • alveolar cells type 1: 5,548 nCPM
  • esophageal apical cells: 1,341 nCPM
  • esophageal suprabasal cells: 1,254 nCPM
  • transitional alveolar cells: 1,136 nCPM
  • suprabasal keratinocytes: 1,052 nCPM
  • esophageal basal cells: 694 nCPM

Immune cell

  • basophil: 1.2 nTPM
  • neutrophil: 0.9 nTPM
  • NK-cell: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • classical monocyte: 0.2 nTPM

Brain region

  • thalamus: 26 nTPM
  • choroid plexus: 26 nTPM
  • midbrain: 22 nTPM
  • medulla oblongata: 20 nTPM
  • pons: 20 nTPM
  • hypothalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EMP2.

Disease | AllUniProt

Conditions EMP2 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 121 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Nephrotic syndrome, type 10

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.88
gnomAD pLI
0
gnomAD missense Z
-0.44
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMP2 as an antibody target. Whether an autoantibody or antibody against EMP2 could matter depends on whether native EMP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMP2 is annotated at the cell surface, where native EMP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label EMP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EMP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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