Seroatlas · Human Serome Atlas

CD63

CD63 antigen

Also known as: CD63_HUMAN, ME491, MLA1, TSPAN30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08962
Gene
CD63
Ensembl
ENSG00000135404
Chromosome
12
Canonical length
238 aa
Protein class
CD markers, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>P08962|CD63
     1  MAVEGGMKCV KFLLYVLLLA FCACAVGLIA VGVGAQLVLS QTIIQGATPG SLLPVVIIAV
    61  GVFLFLVAFV GCCGACKENY CLMITFAIFL SLIMLVEVAA AIAGYVFRDK VMSEFNNNFR
   121  QQMENYPKNN HTASILDRMQ ADFKCCGAAN YTDWEKIPSM SKNRVPDSCC INVTVGCGIN
   181  FNEKAIHKEG CVEKIGGWLR KNVLVVAAAA LGIAFVEVLG IVFACCLVKS IRSGYEVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
1,691 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 1,691 nTPM
  • epididymis: 1,408 nTPM
  • heart muscle: 1,150 nTPM
  • blood vessel: 1,051 nTPM
  • adipose tissue: 907 nTPM
  • skeletal muscle: 889 nTPM

Single-cell type

  • extravillous trophoblasts: 3,957 nCPM
  • hofbauer cells: 3,924 nCPM
  • syncytiotrophoblasts: 3,671 nCPM
  • decidual stromal cells: 3,665 nCPM
  • esophageal apical cells: 2,986 nCPM
  • melanocytes: 2,465 nCPM

Immune cell

  • eosinophil: 1,862 nTPM
  • basophil: 1,286 nTPM
  • total PBMC: 850 nTPM
  • NK-cell: 735 nTPM
  • neutrophil: 658 nTPM
  • classical monocyte: 611 nTPM

Brain region

  • choroid plexus: 381 nTPM
  • thalamus: 336 nTPM
  • hypothalamus: 287 nTPM
  • medulla oblongata: 287 nTPM
  • white matter: 275 nTPM
  • pons: 231 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0.02
gnomAD missense Z
0.77
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD63 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD63 as an antibody target. Whether an autoantibody or antibody against CD63 could matter depends on whether native CD63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD63 is annotated at the cell surface, where native CD63 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD63. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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