Seroatlas · Human Serome Atlas

JAML

Junctional adhesion molecule-like

Also known as: AMICA, AMICA1, Gm638, JAML_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YT9
Gene: JAML
Ensembl: ENSG00000160593
Chromosome: 11
Canonical length: 394 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables integrin binding activity and protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and myeloid leukocyte migration. Located in bicellular tight junction; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q86YT9|JAML
     1  MFCPLKLILL PVLLDYSLGL NDLNVSPPEL TVHVGDSALM GCVFQSTEDK CIFKIDWTLS
    61  PGEHAKDEYV LYYYSNLSVP IGRFQNRVHL MGDILCNDGS LLLQDVQEAD QGTYICEIRL
   121  KGESQVFKKA VVLHVLPEEP KELMVHVGGL IQMGCVFQST EVKHVTKVEW IFSGRRAKEE
   181  IVFRYYHKLR MSVEYSQSWG HFQNRVNLVG DIFRNDGSIM LQGVRESDGG NYTCSIHLGN
   241  LVFKKTIVLH VSPEEPRTLV TPAALRPLVL GGNQLVIIVG IVCATILLLP VLILIVKKTC
   301  GNKSSVNSTV LVKNTKKTNP EIKEKPCHFE RCEGEKHIYS PIIVREVIEE EEPSEKSEAT
   361  YMTMHPVWPS LRSDRNNSLE KKSGGGMPKT QQAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JAML can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

appendix: 65 nTPM
spleen: 59 nTPM
lung: 41 nTPM
small intestine: 30 nTPM
tonsil: 30 nTPM
lymph node: 29 nTPM

Single-cell type

neutrophils: 649 nCPM
cdc: 420 nCPM
pdcs: 285 nCPM
monocytes: 203 nCPM
t-cells: 161 nCPM
macrophages: 137 nCPM

Immune cell

eosinophil: 3,539 nTPM
neutrophil: 2,131 nTPM
classical monocyte: 1,026 nTPM
myeloid DC: 1,019 nTPM
total PBMC: 844 nTPM
plasmacytoid DC: 767 nTPM

Brain region

cerebellum: 3.6 nTPM
choroid plexus: 3.4 nTPM
cerebral cortex: 2.6 nTPM
medulla oblongata: 1.4 nTPM
pons: 0.9 nTPM
spinal cord: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JAML in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JAML as an antibody target. Whether an autoantibody or antibody against JAML could matter depends on whether native JAML is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JAML is annotated at the cell surface, where native JAML is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label JAML as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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