Seroatlas · Human Serome Atlas

FGR

Tyrosine-protein kinase Fgr

Also known as: c-fgr, FGR_HUMAN, p55c-fgr, SRC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09769
Gene: FGR
Ensembl: ENSG00000000938
Chromosome: 1
Canonical length: 529 aa
Protein class: Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Plasma membrane,Aggresome

OverviewNCBI Gene

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>P09769|FGR
     1  MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA
    61  INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL
   121  SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTKGAY
   181  SLSIRDWDQT RGDHVKHYKI RKLDMGGYYI TTRVQFNSVQ ELVQHYMEVN DGLCNLLIAP
   241  CTIMKPQTLG LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP
   301  KAFLEEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE GQDLRLPQLV
   361  DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLACKIAD FGLARLIKDD EYNPCQGSKF
   421  PIKWTAPEAA LFGRFTIKSD VWSFGILLTE LITKGRIPYP GMNKREVLEQ VEQGYHMPCP
   481  PGCPASLYEA MEQTWRLDPE ERPTFEYLQS FLEDYFTSAE PQYQPGDQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 197 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 197 nTPM
spleen: 136 nTPM
lung: 83 nTPM
appendix: 59 nTPM
lymph node: 26 nTPM
adipose tissue: 24 nTPM

Single-cell type

neutrophils: 910 nCPM
monocytes: 408 nCPM
neutrophil progenitors: 307 nCPM
monocyte progenitors: 215 nCPM
kupffer cells: 134 nCPM
cdc: 133 nCPM

Immune cell

total PBMC: 494 nTPM
intermediate monocyte: 469 nTPM
non-classical monocyte: 407 nTPM
classical monocyte: 382 nTPM
neutrophil: 274 nTPM
NK-cell: 265 nTPM

Brain region

cerebral cortex: 19 nTPM
thalamus: 18 nTPM
pons: 12 nTPM
medulla oblongata: 9.8 nTPM
amygdala: 8 nTPM
midbrain: 7.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGR.

Disease | ImmuneIEDB

Conditions an epitope on FGR was assayed in.

psoriasis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.48
gnomAD missense Z: 2.78
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGR as an antibody target. Whether an autoantibody or antibody against FGR could matter depends on whether native FGR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGR is annotated at the cell surface, where native FGR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FGR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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