Seroatlas · Human Serome Atlas

HCK

Tyrosine-protein kinase HCK

Also known as: HCK_HUMAN, JTK9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08631
Gene
HCK
Ensembl
ENSG00000101336
Chromosome
20
Canonical length
526 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>P08631|HCK
     1  MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK
    61  PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL
   121  ATRKEGYIPS NYVARVDSLE TEEWFFKGIS RKDAERQLLA PGNMLGSFMI RDSETTKGSY
   181  SLSVRDYDPR QGDTVKHYKI RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP
   241  CMSSKPQKPW EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE
   301  AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG SKQPLPKLID
   361  FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF GLARVIEDNE YTAREGAKFP
   421  IKWTAPEAIN FGSFTIKSDV WSFGILLMEI VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE
   481  NCPEELYNIM MRCWKNRPEE RPTFEYIQSV LDDFYTATES QYQQQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HCK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 107 nTPM
  • appendix: 94 nTPM
  • bone marrow: 51 nTPM
  • lung: 43 nTPM
  • tonsil: 37 nTPM
  • lymph node: 36 nTPM

Single-cell type

  • neutrophils: 2,705 nCPM
  • tuft cells: 980 nCPM
  • monocytes: 573 nCPM
  • neutrophil progenitors: 434 nCPM
  • kupffer cells: 312 nCPM
  • hofbauer cells: 274 nCPM

Immune cell

  • non-classical monocyte: 1,255 nTPM
  • intermediate monocyte: 1,057 nTPM
  • neutrophil: 803 nTPM
  • eosinophil: 708 nTPM
  • classical monocyte: 574 nTPM
  • total PBMC: 565 nTPM

Brain region

  • choroid plexus: 25 nTPM
  • white matter: 21 nTPM
  • medulla oblongata: 17 nTPM
  • thalamus: 14 nTPM
  • spinal cord: 13 nTPM
  • pons: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HCK.

Disease | AllUniProt

Conditions HCK is implicated in, by any mechanism.

  • Autoinflammation with pulmonary and cutaneous vasculitis (AIPCV) MIM:620296

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 115 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autoinflammation with pulmonary and cutaneous vasculitis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.02
gnomAD missense Z
1.7
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HCK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HCK as an antibody target. Whether an autoantibody or antibody against HCK could matter depends on whether native HCK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HCK is annotated at the cell surface, where native HCK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HCK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HCK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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