Seroatlas · Human Serome Atlas

BCAM

Basal cell adhesion molecule

Also known as: BCAM_HUMAN, CD239, LU

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50895
Gene: BCAM
Ensembl: ENSG00000187244
Chromosome: 19
Canonical length: 628 aa
Protein class: Blood group antigen proteins, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

628 residues, UniProt reviewed canonical sequence.

>P50895|BCAM
     1  MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI LDCTPTGTHD
    61  HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP PYQLDSQGRL VLAEAQVGDE
   121  RDYVCVVRAG AAGTAEATAR LNVFAKPEAT EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA
   181  PKITWYRNGQ RLEVPVEMNP EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH
   241  YSLPEGRHGR LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE
   301  YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL SKTLELRVAY
   361  LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS TPLGDGPMLS LSSITFDSNG
   421  TYVCEASLPT VPVLSRTQNF TLLVQGSPEL KTAEIEPKAD GSWREGDEVT LICSARGHPD
   481  PKLSWSQLGG SPAEPIPGRQ GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV
   541  SPQTSQAGVA VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS
   601  EQPEQTGLLM GGASGGARGG SGGFGDEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCAM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 346 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 346 nTPM
kidney: 339 nTPM
thyroid gland: 219 nTPM
prostate: 139 nTPM
heart muscle: 131 nTPM
breast: 127 nTPM

Single-cell type

cytotrophoblasts: 899 nCPM
vascular smooth muscle cells: 539 nCPM
fallopian secretory cells: 492 nCPM
syncytiotrophoblasts: 485 nCPM
breast myoepithelial cells: 472 nCPM
migrating cytotrophoblasts: 407 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 55 nTPM
hypothalamus: 33 nTPM
thalamus: 33 nTPM
midbrain: 32 nTPM
medulla oblongata: 30 nTPM
pons: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BCAM.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 158 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

BLOOD GROUP--LUTHERAN NULL
BLOOD GROUP--LUTHERAN SYSTEM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCAM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCAM as an antibody target. Whether an autoantibody or antibody against BCAM could matter depends on whether native BCAM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCAM is annotated at the cell surface, where native BCAM is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BCAM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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