Seroatlas · Human Serome Atlas

SEMA7A

Semaphorin-7A

Also known as: CD108, H-Sema-L, SEM7A_HUMAN, SEMAL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75326
Gene
SEMA7A
Ensembl
ENSG00000138623
Chromosome
15
Canonical length
666 aa
Protein class
Blood group antigen proteins, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>O75326|SEMA7A
     1  MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS GPRIFAVWKG
    61  HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF PEGKNASVRT VNIGSTKGSC
   121  LDKRDCENYI TLLERRSEGL LACGTNARHP SCWNLVNGTV VPLGEMRGYA PFSPDENSLV
   181  LFEGDEVYST IRKQEYNGKI PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI
   241  YYFFREDNPD KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF
   301  NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS LKGYHSSLPN
   361  PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP LFHSKYHYQK VAVHRMQASH
   421  GETFHVLYLT TDRGTIHKVV EPGEQEHSFA FNIMEIQPFR RAAAIQTMSL DAERRKLYVS
   481  SQWEVSQVPL DLCEVYGGGC HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE
   541  CPNPKPDKAP LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI
   601  ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS LWLGVLPTLT
   661  LGLLVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEMA7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 62 nTPM
  • spleen: 55 nTPM
  • cerebellum: 36 nTPM
  • retina: 32 nTPM
  • testis: 27 nTPM
  • cerebral cortex: 22 nTPM

Single-cell type

  • oligodendrocytes: 18 nCPM
  • brain excitatory neurons: 12 nCPM
  • tuft cells: 12 nCPM
  • microglia: 11 nCPM
  • megakaryocytes: 6.2 nCPM
  • oligodendrocyte progenitor cells: 4.7 nCPM

Immune cell

  • eosinophil: 3.1 nTPM
  • basophil: 1.8 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • memory B-cell: 0.4 nTPM
  • NK-cell: 0.2 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • pons: 51 nTPM
  • white matter: 46 nTPM
  • cerebellum: 43 nTPM
  • thalamus: 39 nTPM
  • medulla oblongata: 39 nTPM
  • cerebral cortex: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SEMA7A.

Disease | AllUniProt

Conditions SEMA7A is implicated in, by any mechanism.

  • Cholestasis, progressive familial intrahepatic, 11 (PFIC11) MIM:619874

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cholestasis, progressive familial intrahepatic, 11

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.18
gnomAD missense Z
1.84
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEMA7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEMA7A as an antibody target. Whether an autoantibody or antibody against SEMA7A could matter depends on whether native SEMA7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEMA7A is annotated at the cell surface, where native SEMA7A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SEMA7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEMA7A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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