IGFBP1

Protein identityUniProt · HPA

UniProt accession

P08833

Gene

IGFBP1

Ensembl

ENSG00000146678

Chromosome

7

Canonical length

259 aa

Protein class

Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins

Subcellular location

Golgi apparatus

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>P08833|IGFBP1
     1  MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE VTRSAGCGCC
    61  PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG QGACVQESDA SAPHAAEAGS
   121  PESPESTEIT EEELLDNFHL MAPSEEDHSI LWDAISTYDG SKALHVTNIK KWKEPCRIEL
   181  YRVVESLAKA QETSGEEISK FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP
   241  GSPEIRGDPN CQIYFNVQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

1,121 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.19

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• insulin receptor signaling pathway
• negative regulation of canonical Wnt signaling pathway
• positive regulation of cell growth
• regulation of insulin-like growth factor receptor signaling pathway
• signal transduction
• tissue regeneration

Molecular functions

• insulin-like growth factor binding
• insulin-like growth factor I binding
• insulin-like growth factor II binding
• signaling receptor binding

Cellular components

• endoplasmic reticulum lumen
• extracellular region
• extracellular space
• Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

• Thyroglobulin type-1
• Insulin-like growth factor-binding protein, IGFBP
• Growth factor receptor cysteine-rich domain superfamily
• Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
• Insulin-like growth factor-binding protein family 1-6, chordata
• Thyroglobulin type-1 superfamily
• Thyroglobulin type-1 repeat
• Insulin-like growth factor binding protein
• Insulin-like growth factor-binding protein 1

KeywordsUniProt

• Disulfide bond
• Growth factor binding
• Phosphoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IGFBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• VHL
• ITGA5
• ITGB1