Seroatlas · Human Serome Atlas

CCN3

CCN family member 3

Also known as: CCN3_HUMAN, IGFBP9, NOV

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48745
Gene: CCN3
Ensembl: ENSG00000136999
Chromosome: 8
Canonical length: 357 aa
Protein class: Plasma proteins, Predicted secreted proteins, Transporters
Subcellular location: Vesicles,Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>P48745|CCN3
     1  MQSVQSTSFC LRKQCLCLTF LLLHLLGQVA ATQRCPPQCP GRCPATPPTC APGVRAVLDG
    61  CSCCLVCARQ RGESCSDLEP CDESSGLYCD RSADPSNQTG ICTAVEGDNC VFDGVIYRSG
   121  EKFQPSCKFQ CTCRDGQIGC VPRCQLDVLL PEPNCPAPRK VEVPGECCEK WICGPDEEDS
   181  LGGLTLAAYR PEATLGVEVS DSSVNCIEQT TEWTACSKSC GMGFSTRVTN RNRQCEMLKQ
   241  TRLCMVRPCE QEPEQPTDKK GKKCLRTKKS LKAIHLQFKN CTSLHTYKPR FCGVCSDGRC
   301  CTPHNTKTIQ AEFQCSPGQI VKKPVMVIGT CTCHTNCPKN NEAFLQELEL KTTRGKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 1,045 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 1,045 nTPM
blood vessel: 548 nTPM
thyroid gland: 24 nTPM
adipose tissue: 22 nTPM
prostate: 21 nTPM
pituitary gland: 21 nTPM

Single-cell type

adrenal cortex cells: 557 nCPM
endometrial luminal cells: 115 nCPM
vascular smooth muscle cells: 96 nCPM
melanocytes: 80 nCPM
schwann cells: 73 nCPM
mast cells: 60 nCPM

Immune cell

eosinophil: 65 nTPM
neutrophil: 31 nTPM
myeloid DC: 0.4 nTPM
classical monocyte: 0.3 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

hippocampal formation: 28 nTPM
cerebral cortex: 20 nTPM
basal ganglia: 17 nTPM
hypothalamus: 14 nTPM
spinal cord: 12 nTPM
cerebellum: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.01
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCN3 as an antibody target. Whether an autoantibody or antibody against CCN3 could matter depends on whether native CCN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCN3 is annotated at the cell surface, where native CCN3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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