Seroatlas · Human Serome Atlas

CD82

CD82 antigen

Also known as: CD82_HUMAN, IA4, KAI1, R2, ST6, TSPAN27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P27701
Gene
CD82
Ensembl
ENSG00000085117
Chromosome
11
Canonical length
267 aa
Protein class
Cancer-related genes, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles
Quaternary structure
Homooligomer

OverviewNCBI Gene

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>P27701|CD82
     1  MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS SLRMGAYVFI
    61  GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV TAGALFYFNM GKLKQEMGGI
   121  VTELIRDYNS SREDSLQDAW DYVQAQVKCC GWVSFYNWTD NAELMNRPEV TYPCSCEVKG
   181  EEDNSLSVRK GFCEAPGNRT QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI
   241  IELLGMVLSI CLCRHVHSED YSKVPKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
136 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 136 nTPM
  • bone marrow: 132 nTPM
  • lung: 89 nTPM
  • skin: 89 nTPM
  • tonsil: 77 nTPM
  • small intestine: 77 nTPM

Single-cell type

  • neutrophils: 552 nCPM
  • esophageal suprabasal cells: 393 nCPM
  • esophageal basal cells: 269 nCPM
  • esophageal apical cells: 254 nCPM
  • mast cells: 244 nCPM
  • prostatic club cells: 230 nCPM

Immune cell

  • neutrophil: 537 nTPM
  • basophil: 367 nTPM
  • memory B-cell: 309 nTPM
  • naive B-cell: 211 nTPM
  • T-reg: 173 nTPM
  • memory CD4 T-cell: 150 nTPM

Brain region

  • thalamus: 157 nTPM
  • basal ganglia: 152 nTPM
  • midbrain: 140 nTPM
  • white matter: 123 nTPM
  • medulla oblongata: 108 nTPM
  • cerebral cortex: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.09
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD82 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD82 as an antibody target. Whether an autoantibody or antibody against CD82 could matter depends on whether native CD82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD82 is annotated at the cell surface, where native CD82 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD82. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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