Seroatlas · Human Serome Atlas

KANK2

KN motif and ankyrin repeat domain-containing protein 2

Also known as: ANKRD25, KANK2_HUMAN, KIAA1518, MXRA3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q63ZY3
Gene
KANK2
Ensembl
ENSG00000197256
Chromosome
19
Canonical length
851 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

851 residues, UniProt reviewed canonical sequence.

>Q63ZY3|KANK2
     1  MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV DDIEKGHTLR
    61  RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY SYCGRGFYPQ YGALETRGGF
   121  NPRVERTLLD ARRRLEDQAA TPTGLGSLTP SAAGSTASLV GVGLPPPTPR SSGLSTPVPP
   181  SAGHLAHVRE QMAGALRKLR QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT
   241  AGRGRSELCL DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL
   301  QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP AQRAQSLEPY
   361  GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH MVKKISITER SCDGAAGLPE
   421  VPAESSSSPP GSEVASLTQP EKSTGRVPTQ EPTHREPTRQ AASQESEEAG GTGGPPAGVR
   481  SIMKRKEEVA DPTAHRRSLQ FVGVNGGYES SSEDSSTAEN ISDNDSTENE APEPRERVPS
   541  VAEAPQLRPA GTAAAKTSRQ ECQLSRESQH IPTAEGASGS NTEEEIRMEL SPDLISACLA
   601  LEKYLDNPNA LTERELKVAY TTVLQEWLRL ACRSDAHPEL VRRHLVTFRA MSARLLDYVV
   661  NIADSNGNTA LHYSVSHANF PVVQQLLDSG VCKVDKQNRA GYSPIMLTAL ATLKTQDDIE
   721  TVLQLFRLGN INAKASQAGQ TALMLAVSHG RVDVVKALLA CEADVNVQDD DGSTALMCAC
   781  EHGHKEIAGL LLAVPSCDIS LTDRDGSTAL MVALDAGQSE IASMLYSRMN IKCSFAPMSD
   841  DESPTSSSAE E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KANK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
388 nTPM

Expression across tissuesHPA

Tissue

  • colon: 388 nTPM
  • blood vessel: 368 nTPM
  • endometrium: 346 nTPM
  • cervix: 302 nTPM
  • urinary bladder: 264 nTPM
  • smooth muscle: 259 nTPM

Single-cell type

  • smooth muscle cells: 368 nCPM
  • peritubular myoid cells: 270 nCPM
  • vascular smooth muscle cells: 259 nCPM
  • leydig cells: 148 nCPM
  • pericytes: 147 nCPM
  • endometrial stromal cells: 141 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • basophil: 0.1 nTPM
  • classical monocyte: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • thalamus: 44 nTPM
  • medulla oblongata: 43 nTPM
  • hypothalamus: 40 nTPM
  • pons: 39 nTPM
  • basal ganglia: 38 nTPM
  • midbrain: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KANK2.

Disease | AllUniProt

Conditions KANK2 is implicated in, by any mechanism.

  • Palmoplantar keratoderma and woolly hair (PPKWH) MIM:616099
  • Nephrotic syndrome 16 (NPHS16) MIM:617783

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 562 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Nephrotic syndrome 16
  • Wooly hair-palmoplantar keratoderma syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.04
gnomAD missense Z
0.48
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KANK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KANK2 as an antibody target. Whether an autoantibody or antibody against KANK2 could matter depends on whether native KANK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KANK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KANK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KANK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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