EIF4EBP3
Eukaryotic translation initiation factor 4E-binding protein 3
Also known as: 4E-BP3, 4EBP3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O60516
- Gene
- EIF4EBP3
- Ensembl
- ENSG00000243056
- Chromosome
- 5
- Canonical length
- 100 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Canonical amino-acid sequenceUniProt
100 residues, UniProt reviewed canonical sequence.
>O60516|EIF4EBP3
1 MSTSTSCPIP GGRDQLPDCY STTPGGTLYA TTPGGTRIIY DRKFLLECKN SPIARTPPCC
61 LPQIPGVTTP PTAPLSKLEE LKEQETEEEI PDDAQFEMDILocalizationUniProt · AlphaFold · HPA
Whether an antibody against EIF4EBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 116 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 116 nTPM
- choroid plexus: 66 nTPM
- adrenal gland: 65 nTPM
- stomach: 56 nTPM
- liver: 53 nTPM
- tongue: 52 nTPM
Single-cell type
- parietal cells: 39 nCPM
- epididymal clear cells: 37 nCPM
- epididymal efferent duct absorptive cells: 36 nCPM
- enterocytes: 34 nCPM
- gastric chief cells: 30 nCPM
- enteric stem cells: 24 nCPM
Immune cell
- plasmacytoid DC: 118 nTPM
- intermediate monocyte: 51 nTPM
- classical monocyte: 44 nTPM
- naive CD4 T-cell: 42 nTPM
- memory B-cell: 42 nTPM
- non-classical monocyte: 39 nTPM
Brain region
- hypothalamus: 22 nTPM
- choroid plexus: 21 nTPM
- white matter: 21 nTPM
- medulla oblongata: 21 nTPM
- spinal cord: 21 nTPM
- cerebellum: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.83
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.09
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of EIF4EBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EIF4EBP3 as an antibody target. Whether an autoantibody or antibody against EIF4EBP3 could matter depends on whether native EIF4EBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EIF4EBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EIF4EBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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