Seroatlas · Human Serome Atlas

ANGEL1

Protein angel homolog 1

Also known as: ANGE1_HUMAN, Ccr4e, KIAA0759

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UNK9
Gene
ANGEL1
Ensembl
ENSG00000013523
Chromosome
14
Canonical length
670 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. Is active in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>Q9UNK9|ANGEL1
     1  MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR GPEQEECEGL
    61  LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE ENAASEDRWS SRQLSDLRAA
   121  ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI PMQSEPQYAD CAALPVGALA TEQWEEDPAV
   181  LAWSIAPEPV PQEEASIWPF EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG
   241  PQFQFTLMSY NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ
   301  EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE YFRPGLELLN
   361  RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG DVKLAQMAIL LAEVDKVARL
   421  SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL
   481  WPSSLGITDC CQYVTSCHPK RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE
   541  RPAGWAESVL EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT
   601  VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP FCSSDHLCLL
   661  ASFGMEVTAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGEL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • testis: 49 nTPM
  • pancreas: 48 nTPM
  • spleen: 28 nTPM
  • retina: 24 nTPM
  • epididymis: 23 nTPM
  • spinal cord: 22 nTPM

Single-cell type

  • late spermatids: 131 nCPM
  • early spermatids: 117 nCPM
  • oligodendrocyte progenitor cells: 117 nCPM
  • sertoli cells: 90 nCPM
  • microglia: 85 nCPM
  • rod photoreceptor cells: 58 nCPM

Immune cell

  • myeloid DC: 7.5 nTPM
  • naive CD4 T-cell: 7.5 nTPM
  • MAIT T-cell: 7.2 nTPM
  • non-classical monocyte: 7.1 nTPM
  • memory B-cell: 6.9 nTPM
  • gdT-cell: 5.9 nTPM

Brain region

  • white matter: 52 nTPM
  • medulla oblongata: 52 nTPM
  • cerebral cortex: 48 nTPM
  • pons: 48 nTPM
  • hypothalamus: 47 nTPM
  • thalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
0.92
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANGEL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANGEL1 as an antibody target. Whether an autoantibody or antibody against ANGEL1 could matter depends on whether native ANGEL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANGEL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANGEL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANGEL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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