TDO2

Protein identityUniProt · HPA

UniProt accession

P48775

Gene

TDO2

Ensembl

ENSG00000151790

Chromosome

4

Canonical length

406 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Plasma membrane,Primary cilium,Basal body,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>P48775|TDO2
     1  MSGCPFLGNN FGYTFKKLPV EGSEEDKSQT GVNRASKGGL IYGNYLHLEK VLNAQELQSE
    61  TKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVSRMHRVSV
   121  ILKLLVQQFS ILETMTALDF NDFREYLSPA SGFQSLQFRL LENKIGVLQN MRVPYNRRHY
   181  RDNFKGEENE LLLKSEQEKT LLELVEAWLE RTPGLEPHGF NFWGKLEKNI TRGLEEEFIR
   241  IQAKEESEEK EEQVAEFQKQ KEVLLSLFDE KRHEHLLSKG ERRLSYRALQ GALMIYFYRE
   301  EPRFQVPFQL LTSLMDIDSL MTKWRYNHVC MVHRMLGSKA GTGGSSGYHY LRSTVSDRYK
   361  VFVDLFNLST YLIPRHWIPK MNPTIHKFLY TAEYCDSSYF SSDESD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

740 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TDO2.

Disease | AllUniProt

Conditions TDO2 is implicated in, by any mechanism.

• Hypertryptophanemia (HYPTRP) MIM:600627

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.04

gnomAD pLI

0

gnomAD missense Z

-0.22

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• L-tryptophan catabolic process to kynurenine
• protein homotetramerization
• response to cortisol
• response to ethanol
• L-tryptophan catabolic process to acetyl-CoA
• response to nitroglycerin

Molecular functions

• amino acid binding
• heme binding
• identical protein binding
• L-tryptophan 2,3-dioxygenase activity
• metal ion binding
• oxygen binding

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Tryptophan/Indoleamine 2,3-dioxygenase-like
• Tryptophan 2,3-dioxygenase
• Tryptophan 2,3-dioxygenase

KeywordsUniProt

• Dioxygenase
• Heme
• Iron
• Metal-binding
• Oxidoreductase
• Tryptophan catabolism

InteractionsUniProt · HPA

Protein binding partners of TDO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ASMTL
• EIF4E
• NMNAT1
• SDCBP