HHEX
Hematopoietically-expressed homeobox protein HHEX
Also known as: HEX, HHEX_HUMAN, HOX11L-PEN, PRHX
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q03014
- Gene
- HHEX
- Ensembl
- ENSG00000152804
- Chromosome
- 10
- Canonical length
- 270 aa
- Protein class
- Human disease related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear bodies
OverviewNCBI Gene
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
270 residues, UniProt reviewed canonical sequence.
>Q03014|HHEX
1 MQYPHPGPAA GAVGVPLYAP TPLLQPAHPT PFYIEDILGR GPAAPTPAPT LPSPNSSFTS
61 LVSPYRTPVY EPTPIHPAFS HHSAAALAAA YGPGGFGGPL YPFPRTVNDY THALLRHDPL
121 GKPLLWSPFL QRPLHKRKGG QVRFSNDQTI ELEKKFETQK YLSPPERKRL AKMLQLSERQ
181 VKTWFQNRRA KWRRLKQENP QSNKKEELES LDSSCDQRQD LPSEQNKGAS LDSSQCSPSP
241 ASQEDLESEI SEDSDQEVDI EGDKSYFNAGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HHEX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 97 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 97 nTPM
- liver: 88 nTPM
- bone marrow: 80 nTPM
- spleen: 38 nTPM
- lymph node: 37 nTPM
- pancreas: 36 nTPM
Single-cell type
- pancreatic duct cells: 158 nCPM
- platelets: 156 nCPM
- cholangiocytes: 145 nCPM
- hofbauer cells: 139 nCPM
- oocytes: 92 nCPM
- lymphatic endothelial cells: 73 nCPM
Immune cell
- naive B-cell: 66 nTPM
- eosinophil: 62 nTPM
- memory B-cell: 60 nTPM
- non-classical monocyte: 51 nTPM
- intermediate monocyte: 46 nTPM
- classical monocyte: 42 nTPM
Brain region
- white matter: 7.6 nTPM
- medulla oblongata: 7 nTPM
- pons: 6.8 nTPM
- spinal cord: 6.7 nTPM
- thalamus: 6.1 nTPM
- cerebellum: 5.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.58
- gnomAD pLI
- 0.54
- gnomAD missense Z
- 1.36
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anterior/posterior pattern specification
- B cell differentiation
- cell differentiation
- DNA conformation change
- negative regulation of angiogenesis
- negative regulation of DNA-templated transcription
- negative regulation of transcription by competitive promoter binding
- negative regulation of transcription by RNA polymerase II
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- positive regulation of canonical Wnt signaling pathway
- positive regulation of DNA-templated transcription
- positive regulation of transcription by RNA polymerase II
- positive regulation of Wnt signaling pathway
- protein localization to nucleus
- regulation of mRNA export from nucleus
- regulation of transcription by RNA polymerase II
- Wnt signaling pathway
- negative regulation of cytoplasmic translational initiation
- regulation of leukocyte proliferation
Molecular functions
- DNA binding, bending
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- eukaryotic initiation factor 4E binding
- protein homodimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- TBP-class protein binding
- transcription cis-regulatory region binding
- translation regulator activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HHEX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HHEX as an antibody target. Whether an autoantibody or antibody against HHEX could matter depends on whether native HHEX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HHEX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HHEX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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