Seroatlas · Human Serome Atlas

NGDN

Neuroguidin

Also known as: C14orf120, CANu1, DKFZP564O092, LCP5, lpd-2, NGD, NGDN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEJ9
Gene: NGDN
Ensembl: ENSG00000129460
Chromosome: 14
Canonical length: 315 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8NEJ9|NGDN
     1  MAALGVLESD LPSAVTLLKN LQEQVMAVTA QVKSLTQKVQ AGAYPTEKGL SFLEVKDQLL
    61  LMYLMDLTHL ILDKASGGSL QGHDAVLRLV EIRTVLEKLR PLDQKLKYQI DKLIKTAVTG
   121  SLSENDPLRF KPHPSNMMSK LSSEDEEEDE AEDDQSEASG KKSVKGVSKK YVPPRLVPVH
   181  YDETEAEREK KRLERAKRRA LSSSVIRELK EQYSDAPEEI RDARHPHVTR QSQEDQHRIN
   241  YEESMMVRLS VSKREKGRRK RANVMSSQLH SLTHFSDISA LTGGTVHLDE DQNPIKKRKK
   301  IPQKGRKKKG FRRRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NGDN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 53 nTPM
bone marrow: 51 nTPM
cerebellum: 37 nTPM
blood vessel: 36 nTPM
breast: 36 nTPM
skin: 35 nTPM

Single-cell type

oocytes: 120 nCPM
differentiating spermatogonia: 80 nCPM
early primary spermatocytes: 78 nCPM
cytotrophoblasts: 78 nCPM
migrating cytotrophoblasts: 76 nCPM
syncytiotrophoblasts: 73 nCPM

Immune cell

memory B-cell: 126 nTPM
naive CD4 T-cell: 119 nTPM
T-reg: 114 nTPM
naive B-cell: 106 nTPM
NK-cell: 106 nTPM
naive CD8 T-cell: 94 nTPM

Brain region

white matter: 24 nTPM
cerebellum: 22 nTPM
spinal cord: 18 nTPM
basal ganglia: 18 nTPM
medulla oblongata: 17 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.72
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NGDN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NGDN as an antibody target. Whether an autoantibody or antibody against NGDN could matter depends on whether native NGDN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NGDN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NGDN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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