Seroatlas · Human Serome Atlas

BTG4

Protein BTG4

Also known as: APRO3, BTG4_HUMAN, PC3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NY30
Gene
BTG4
Ensembl
ENSG00000137707
Chromosome
11
Canonical length
223 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q9NY30|BTG4
     1  MRDEIATTVF FVTRLVKKHD KLSKQQIEDF AEKLMTILFE TYRSHWHSDC PSKGQAFRCI
    61  RINNNQNKDP ILERACVESN VDFSHLGLPK EMTIWVDPFE VCCRYGEKNH PFTVASFKGR
   121  WEEWELYQQI SYAVSRASSD VSSGTSCDEE SCSKEPRVIP KVSNPKSIYQ VENLKQPFQS
   181  WLQIPRKKNV VDGRVGLLGN TYHGSQKHPK CYRPAMHRLD RIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • testis: 21 nTPM
  • choroid plexus: 4.2 nTPM
  • fallopian tube: 1.4 nTPM
  • lung: 0.4 nTPM
  • pancreas: 0.1 nTPM
  • thymus: 0.1 nTPM

Single-cell type

  • late spermatids: 280 nCPM
  • late primary spermatocytes: 147 nCPM
  • early spermatids: 115 nCPM
  • respiratory ciliated cells: 55 nCPM
  • early primary spermatocytes: 34 nCPM
  • ependymal cells: 31 nCPM

Immune cell

  • T-reg: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • midbrain: 2 nTPM
  • medulla oblongata: 1.4 nTPM
  • pons: 0.9 nTPM
  • spinal cord: 0.7 nTPM
  • hippocampal formation: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BTG4.

Disease | AllUniProt

Conditions BTG4 is implicated in, by any mechanism.

  • Oocyte/zygote/embryo maturation arrest 8 (OZEMA8) MIM:619009

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 39 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Oocyte maturation defect 8

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0.17
gnomAD missense Z
0.24
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of BTG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTG4 as an antibody target. Whether an autoantibody or antibody against BTG4 could matter depends on whether native BTG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTG4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BTG4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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