Seroatlas · Human Serome Atlas

MKNK2

MAP kinase-interacting serine/threonine-protein kinase 2

Also known as: GPRK7, MKNK2_HUMAN, MNK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBH9
Gene
MKNK2
Ensembl
ENSG00000099875
Chromosome
19
Canonical length
465 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nuclear bodies

OverviewNCBI Gene

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q9HBH9|MKNK2
     1  MVQKKPAELQ GFHRSFKGQN PFELAFSLDQ PDHGDSDFGL QCSARPDMPA SQPIDIPDAK
    61  KRGKKKKRGR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CINLITSQEY AVKIIEKQPG
   121  HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHKRRHFNEL
   181  EASVVVQDVA SALDFLHNKG IAHRDLKPEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS
   241  PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGRCG
   301  SDCGWDRGEA CPACQNMLFE SIQEGKYEFP DKDWAHISCA AKDLISKLLV RDAKQRLSAA
   361  QVLQHPWVQG CAPENTLPTP MVLQRNSCAK DLTSFAAEAI AMNRQLAQHD EDLAEEEAAG
   421  QGQPVLVRAT SRCLQLSPPS QSKLAQRRQR ASLSSAPVVL VGDHA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MKNK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
1,308 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 1,308 nTPM
  • tongue: 515 nTPM
  • esophagus: 269 nTPM
  • pancreas: 205 nTPM
  • liver: 135 nTPM
  • vagina: 134 nTPM

Single-cell type

  • esophageal apical cells: 727 nCPM
  • esophageal suprabasal cells: 320 nCPM
  • pancreatic acinar cells: 296 nCPM
  • thymic myoid cells: 283 nCPM
  • neutrophils: 272 nCPM
  • breast lactating cells: 260 nCPM

Immune cell

  • neutrophil: 42 nTPM
  • memory B-cell: 17 nTPM
  • naive B-cell: 15 nTPM
  • non-classical monocyte: 14 nTPM
  • T-reg: 13 nTPM
  • intermediate monocyte: 10 nTPM

Brain region

  • cerebellum: 165 nTPM
  • white matter: 127 nTPM
  • medulla oblongata: 107 nTPM
  • choroid plexus: 107 nTPM
  • basal ganglia: 100 nTPM
  • thalamus: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
0.89
DepMap mean gene effect
0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MKNK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MKNK2 as an antibody target. Whether an autoantibody or antibody against MKNK2 could matter depends on whether native MKNK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MKNK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MKNK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MKNK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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