Seroatlas · Human Serome Atlas

ZNF598

E3 ubiquitin-protein ligase ZNF598

Also known as: ZN598_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UK7
Gene: ZNF598
Canonical length: 904 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ZNF598 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q86UK7|ZNF598
     1  MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
    61  EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
   121  RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
   181  TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
   241  LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
   301  VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
   361  ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
   421  PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
   481  FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
   541  GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
   601  TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
   661  PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
   721  PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
   781  HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
   841  LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA
   901  RIIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF598 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

pancreas: 17 nTPM
skin: 12 nTPM
skeletal muscle: 12 nTPM
bone marrow: 11 nTPM
salivary gland: 11 nTPM
spleen: 8.5 nTPM

Single-cell type

goblet cells: 35 nCPM
breast lactating cells: 30 nCPM
suprabasal keratinocytes: 29 nCPM
foveolar cells: 28 nCPM
basal keratinocytes: 28 nCPM
esophageal apical cells: 28 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 14 nTPM
cerebral cortex: 14 nTPM
thalamus: 14 nTPM
midbrain: 13 nTPM
pons: 13 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.55
gnomAD missense Z: -0.92

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Zinc finger C2H2-type
ZN598/HEL22, RING finger
ZNF598/HEL2
ZNF598/HEL2, C2H2 zinc finger
ZNF598/HEL2, PAH domain
ZNF598, C2H2 zinc finger domain
ZNF598 PAH domain
ZNF598 C2H2 zinc finger domain
C2H2-type zinc finger
ZNF598 RING finger domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF598 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF598 as an antibody target. Whether an autoantibody or antibody against ZNF598 could matter depends on whether native ZNF598 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF598 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF598 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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