Seroatlas · Human Serome Atlas

EIF3F

Eukaryotic translation initiation factor 3 subunit F

Also known as: eIF3-epsilon, eIF3-p47, EIF3F_HUMAN, EIF3S5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00303
Gene
EIF3F
Ensembl
ENSG00000175390
Chromosome
11
Canonical length
357 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity and metal-dependent deubiquitinase activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive intellectual developmental disorder 67. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>O00303|EIF3F
     1  MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG
    61  QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL
   121  LGTVDKHSVE VTNCFSVPHN ESEDEVAVDM EFAKNMYELH KKVSPNELIL GWYATGHDIT
   181  EHSVLIHEYY SREAPNPIHL TVDTSLQNGR MSIKAYVSTL MGVPGRTMGV MFTPLTVKYA
   241  YYDTERIGVD LIMKTCFSPN RVIGLSSDLQ QVGGASARIQ DALSTVLQYA EDVLSGKVSA
   301  DNTVGRFLMS LVNQVPKIVP DDFETMLNSN INDLLMVTYL ANLTQSQIAL NEKLVNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 37 nTPM
  • skeletal muscle: 35 nTPM
  • ovary: 32 nTPM
  • skin: 26 nTPM
  • blood vessel: 25 nTPM
  • tonsil: 24 nTPM

Single-cell type

  • late spermatids: 1,226 nCPM
  • extravillous trophoblasts: 766 nCPM
  • cytotrophoblasts: 706 nCPM
  • decidual stromal cells: 699 nCPM
  • migrating cytotrophoblasts: 658 nCPM
  • syncytiotrophoblasts: 568 nCPM

Immune cell

  • total PBMC: 246 nTPM
  • T-reg: 178 nTPM
  • memory B-cell: 175 nTPM
  • naive B-cell: 163 nTPM
  • naive CD4 T-cell: 156 nTPM
  • myeloid DC: 131 nTPM

Brain region

  • cerebellum: 25 nTPM
  • medulla oblongata: 24 nTPM
  • white matter: 24 nTPM
  • amygdala: 24 nTPM
  • hippocampal formation: 23 nTPM
  • thalamus: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF3F.

Disease | AllUniProt

Conditions EIF3F is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal recessive 67 (MRT67) MIM:618295

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 96 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
-0.11
DepMap mean gene effect
-1.46
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3F as an antibody target. Whether an autoantibody or antibody against EIF3F could matter depends on whether native EIF3F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3F. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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