BRSK2

Protein identityUniProt · HPA

UniProt accession

Q8IWQ3

Gene

BRSK2

Ensembl

ENSG00000174672

Chromosome

11

Canonical length

736 aa

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Golgi apparatus

OverviewNCBI Gene

Enables several functions, including ATP binding activity; ATPase binding activity; and magnesium ion binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

736 residues, UniProt reviewed canonical sequence.

>Q8IWQ3|BRSK2
     1  MTSTGKDGGA QHAQYVGPYR LEKTLGKGQT GLVKLGVHCV TCQKVAIKIV NREKLSESVL
    61  MKVEREIAIL KLIEHPHVLK LHDVYENKKY LYLVLEHVSG GELFDYLVKK GRLTPKEARK
   121  FFRQIISALD FCHSHSICHR DLKPENLLLD EKNNIRIADF GMASLQVGDS LLETSCGSPH
   181  YACPEVIRGE KYDGRKADVW SCGVILFALL VGALPFDDDN LRQLLEKVKR GVFHMPHFIP
   241  PDCQSLLRGM IEVDAARRLT LEHIQKHIWY IGGKNEPEPE QPIPRKVQIR SLPSLEDIDP
   301  DVLDSMHSLG CFRDRNKLLQ DLLSEEENQE KMIYFLLLDR KERYPSQEDE DLPPRNEIDP
   361  PRKRVDSPML NRHGKRRPER KSMEVLSVTD GGSPVPARRA IEMAQHGQRS RSISGASSGL
   421  STSPLSSPRV TPHPSPRGSP LPTPKGTPVH TPKESPAGTP NPTPPSSPSV GGVPWRARLN
   481  SIKNSFLGSP RFHRRKLQVP TPEEMSNLTP ESSPELAKKS WFGNFISLEK EEQIFVVIKD
   541  KPLSSIKADI VHAFLSIPSL SHSVISQTSF RAEYKATGGP AVFQKPVKFQ VDITYTEGGE
   601  AQKENGIYSV TFTLLSGPSR RFKRVVETIQ AQLLSTHDPP AAQHLSDTTN CMEMMTGRLS
   661  KCGSPLSNFF DVIKQLFSDE KNGQAAQAPS TPAKRSAHGP LGDSAAAGPG PGGDAEYPTG
   721  KDTAKMGPPT ARREQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRSK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

97 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BRSK2.

Disease | GeneticClinVar

33 pathogenic / likely-pathogenic of 333 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Autosomal dominant non-syndromic intellectual disability
• Inborn genetic diseases
• BRSK2-related disorder
• Neurodevelopmental delay
• BRSK2-associated neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.33

gnomAD pLI

0.95

gnomAD missense Z

2.95

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin cytoskeleton organization
• axonogenesis
• cell division
• central nervous system neuron differentiation
• ERAD pathway
• establishment of cell polarity
• exocytosis
• G2/M transition of mitotic cell cycle
• intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
• microtubule cytoskeleton organization involved in establishment of planar polarity
• neuron differentiation
• protein phosphorylation
• regulation of axonogenesis
• regulation of insulin secretion involved in cellular response to glucose stimulus
• regulation of neuron projection development
• regulation of synaptic vesicle clustering
• regulation of retrograde protein transport, ER to cytosol

Molecular functions

• ATP binding
• ATPase binding
• ATPase regulator activity
• magnesium ion binding
• protein kinase binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• tau protein binding
• tau-protein kinase activity

Cellular components

• centrosome
• cytoplasm
• distal axon
• endoplasmic reticulum
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• BRSK1/2-like, UBA domain
• Protein kinase domain
• BRSK1/2 UBA domain
• BRSK1/2 KA1 domain

KeywordsUniProt

• Apoptosis
• ATP-binding
• Cell cycle
• Cell division
• Cytoplasm
• Cytoskeleton
• Endoplasmic reticulum
• Exocytosis
• Kinase
• Magnesium
• Metal-binding
• Mitosis
• Neurogenesis
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of BRSK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• COPS5
• FZR1
• PAK1
• CDK16